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Neurochemical Research

, Volume 37, Issue 6, pp 1192–1200 | Cite as

Drug Resistance in Glioblastoma: A Mini Review

  • Catherine P. Haar
  • Preetha Hebbar
  • Gerald C. WallaceIV
  • Arabinda Das
  • William A. VandergriftIII
  • Joshua A. Smith
  • Pierre Giglio
  • Sunil J. Patel
  • Swapan K. Ray
  • Naren L. Banik
Overview

Abstract

Glioblastoma multiforme (GBM) is recognized as the most common and lethal form of central nervous system cancer. Currently used surgical techniques, chemotherapeutic agents, and radiotherapy strategies have done very little in extending the life expectancies of patients diagnosed with GBM. The difficulty in treating this malignant disease lies both in its inherent complexity and numerous mechanisms of drug resistance. In this review, we summarize several of the primary mechanisms of drug resistance. We reviewed available published literature in the English language regarding drug resistance in glioblastoma. The reasons for drug resistance in glioblastoma include drug efflux, hypoxic areas of tumor cells, cancer stem cells, DNA damage repair, and miRNAs. Many potential therapies target these mechanisms, including a series of investigated alternative and plant-derived agents. Future research and clinical trials in glioblastoma patients should pursue combination of therapies to help combat drug resistance. The emerging new data on the potential of plant-derived therapeutics should also be closely considered and further investigated.

Keywords

Glioblastoma multiforme Multidrug resistance Glioblastoma stem cells p-Glycoprotein Hypoxia-inducible factors miRNAs Alternative therapies 

Notes

Acknowledgments

Completion of this project was made possible by funding from the National Institutes of Health (NIH) grants (NS-31622, NS-38146, NS-57811, and NS-41088), the State of South Carolina Spinal Cord Injury Research Fund (SCIRF), and Jerry Zucker Fund for Brain Tumor Research at the MUSC Foundation.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Catherine P. Haar
    • 1
  • Preetha Hebbar
    • 1
  • Gerald C. WallaceIV
    • 1
  • Arabinda Das
    • 1
  • William A. VandergriftIII
    • 1
  • Joshua A. Smith
    • 1
  • Pierre Giglio
    • 1
  • Sunil J. Patel
    • 1
  • Swapan K. Ray
    • 2
  • Naren L. Banik
    • 1
  1. 1.Divisions of Neurology and Neurosurgery, Department of NeurosciencesMedical University of South CarolinaCharlestonUSA
  2. 2.Department of Pathology, Microbiology, and ImmunologyUniversity of South Carolina School of MedicineColumbiaUSA

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