Neurochemical Research

, Volume 37, Issue 4, pp 869–874 | Cite as

Amelioration of Age Associated Neuroinflammation on Long Term Bacosides Treatment

  • Manisha Rastogi
  • Rudra P. Ojha
  • B. Parimala Devi
  • Aabha Aggarwal
  • Aruna Agrawal
  • G. P. DubeyEmail author
Original Paper


Bacopa monnieri (L.) is a revered medicinal plant of traditional Indian system of medicine effective against cognitive impairment in ageing and SDAT. In our previous study, long term administration of bacosides was found to exhibit remarkable anti ageing effect, ameliorate age associated neurochemical and neurobehavioral deficits and prevent hippocampal neuronal degeneration in middle aged and aged rat brain cortex. In continuation to the previous study, the present study aims to investigate the neuroprotective effect of bacosides against age related chronic neuroinflammation in Wistar rat brain on 3 months treatment. Recently, neuroinflammation has gained considerable interest in age associated neurodegeneration and pathologies like SDAT due to its slow onset and chronic nature. The results of the present study demonstrated the significant attenuation of age dependant elevation of pro inflammatory cytokines, iNOS protein expression, total nitrite and lipofuscin content in middle aged and aged rat brain cortex on long term oral administration of bacosides. Thus, the present results suggest that bacosides possess immense potential to act as a neuroprotective agent due to its pleiotropic action for the prevention of ageing complications and SDAT progression.


Ageing SDAT Inflammation Lipofuscin Bacosides 



We acknowledge the Vice Chancellor, SASTRA University for granting permission to carry out this work in Centre for Advanced Research in Indian System of Medicine (CARISM).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Manisha Rastogi
    • 1
  • Rudra P. Ojha
    • 1
  • B. Parimala Devi
    • 2
  • Aabha Aggarwal
    • 3
  • Aruna Agrawal
    • 4
  • G. P. Dubey
    • 5
    Email author
  1. 1.Centre for Advanced Research in Indian System of Medicine (CARISM)SASTRA UniversityThanjavurIndia
  2. 2.Department of Pharmacy, School of Chemical and BiotechnologySASTRA UniversityThanjavurIndia
  3. 3.National Institute of Medical Statistics, ICMRNew DelhiIndia
  4. 4.Centre for Psychosomatic and Biofeedback Medicine, IMSBanaras Hindu UniversityVaranasiIndia
  5. 5.Emeritus Scientist, CCRAS, Department of AYUSHMinistry of Health and Family WelfareNew DelhiIndia

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