Neurochemical Research

, Volume 36, Issue 10, pp 1939–1944 | Cite as

Decreased Expression of Lysosomal Alpha-Galactosiase A Gene in Sporadic Parkinson’s Disease

  • Guanghua Wu
  • Jian Huang
  • Xungang Feng
  • Aimei Zhang
  • Jifeng Li
  • Shuchao Pang
  • Kejin Gu
  • Haixin Dong
  • Junping Zhang
  • Huijie Gao
  • Bo Yan
Original Paper

Abstract

Parkinson’s disease (PD) is a progressive neurodegenerative disease. To date, the causal genes and variants associated with sporadic PD are largely unknown. Accumulating evidence demonstrates that autophagy delivers alpha-syncuclein proteins to lysosome for degradation and dysfunctional autophagy is involved in the PD pathogenesis. We have previously screened a group of lysosomal hydrolases and found that alpha-galactosidase A (GLA) activity is significantly decreased in the peripheral leukocytes of sporadic PD patients. In this study, GLA transcript and protein levels were semi-quantitatively examined. The GLA transcript (P = 0.020) and protein (P = 0.027) levels in the peripheral leukocytes of sporadic PD patients were significantly decreased, compared to age- and sex-matched healthy controls. Furthermore, decreased GLA gene expression levels were strongly associated with sporadic PD (OR 3.33, 95%CI 1.17–9.52, P = 0.024). Therefore, our data suggest that insufficient GLA activity may contribute to the pathogenesis of sporadic PD. The underlying molecular mechanisms remain to be determined.

Keywords

Parkinson’s disease Lysosome Alpha-galactosidase A Gene expression Leukocytes 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Guanghua Wu
    • 1
    • 2
  • Jian Huang
    • 2
  • Xungang Feng
    • 3
  • Aimei Zhang
    • 3
  • Jifeng Li
    • 3
  • Shuchao Pang
    • 2
  • Kejin Gu
    • 3
  • Haixin Dong
    • 4
  • Junping Zhang
    • 2
  • Huijie Gao
    • 5
  • Bo Yan
    • 2
  1. 1.Division of Cardiac SurgeryJining Medical College Affiliated Hospital, Jining Medical CollegeJiningChina
  2. 2.Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and TreatmentJining Medical College Affiliated Hospital, Jining Medical CollegeJiningChina
  3. 3.Division of NeurologyJining Medical College Affiliated Hospital, Jining Medical CollegeJiningChina
  4. 4.Division of Experimental MedicineJining Medical College Affiliated Hospital, Jining Medical CollegeJiningChina
  5. 5.Department of ImmunologyJining Medical CollegeJiningChina

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