Neurochemical Research

, Volume 36, Issue 7, pp 1270–1279 | Cite as

Regulation of Cortical Neuron Migration by the Reelin Signaling Pathway

  • Takao Honda
  • Kazuma Kobayashi
  • Katsuhiko Mikoshiba
  • Kazunori Nakajima
Original Paper


Reeler is a mutant mouse with defects in layered structures of the central nervous system, such as the cerebral cortex, hippocampus, and cerebellum, and has been extensively examined for more than half a century. The full-length cDNA for the responsible gene for reeler, reelin, was serendipitously identified, revealing that Reelin encodes a large secreted protein. So far, two Reelin receptors, apolipoprotein E receptor 2 and very low-density lipoprotein receptor, and the cytoplasmic adaptor protein Disabled homolog 1 (Dab1) have been shown to be essential for Reelin signaling. Although a number of downstream cascades of Dab1 have also been reported using various experimental systems, the physiological functions of Reelin in vivo remain controversial. Here, we review recent advances in the understanding of the Reelin-Dab1 signaling pathway in the developing cerebral cortex.


Reeler Reelin Dab1 ApoER2 VLDLR 



This work was supported by the Strategic Research Program for Brain Sciences (“Understanding of molecular and environmental bases for brain health”), the Ministry of Education, Culture, Sports, Science, and Technology of Japan, the Japan Society for the Promotion of Science, the Japan Brain Foundation, the Takeda Science Foundation, the Keio Gijuku Academic Development Funds, and the Promotion and Mutual Aid Corporation for Private Schools of Japan.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Takao Honda
    • 1
  • Kazuma Kobayashi
    • 1
  • Katsuhiko Mikoshiba
    • 2
  • Kazunori Nakajima
    • 1
  1. 1.Department of AnatomyKeio University School of MedicineShinjuku-ku, TokyoJapan
  2. 2.Laboratory for Developmental NeurobiologyRIKEN Brain Science InstituteWako, SaitamaJapan

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