Neurochemical Research

, Volume 36, Issue 3, pp 460–466 | Cite as

Maternal Deprivation Induces Depressive-like Behaviour and Alters Neurotrophin Levels in the Rat Brain

  • Gislaine Z. Réus
  • Roberto B. Stringari
  • Karine F. Ribeiro
  • Andreza L. Cipriano
  • Bruna S. Panizzutti
  • Laura Stertz
  • Camila Lersch
  • Flávio Kapczinski
  • João Quevedo
Original Paper


The present study was aimed to evaluate the behavioral and molecular effects of maternal deprivation in adult rats. To this aim, male rats deprived and non-deprived were assessed in the forced swimming and open-field tests in adult phase. In addition adrenocorticotrophin hormone (ACTH) levels was assessed in serum and brain-derived-neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and nerve growth factor (NGF) protein levels were assessed in prefrontal cortex, hippocampus and amygdala. We observed that maternal deprivation increased immobility time, and decreased climbing time, without affecting locomotor activity. ACTH circulating levels were increased in maternal deprived rats. Additionally, BDNF protein levels were reduced in the amygdala and NT-3 and NGF were reduced in both hippocampus and amygdala in maternal deprived rats, compared to control group. In conclusion, our results support the idea that behavioral, ACTH circulating levels and neurotrophins levels altered in maternal deprivation model could contribute to stress-related diseases, such as depression.


Brain-derived-neurotrophic factor Neurotrophin-3 Nerve growth factor Maternal deprivation Depression 



This study was supported in part by grants from CNPq-Brazil (JQ and FK), FAPESC-Brazil (JQ), Instituto Cérebro e Mente-Brazil (JQ and FK) and UNESC-Brazil (JQ). JQ and FK are recipients of CNPq (Brazil) Productivity fellowships. GZR is holder of a FAPESC studentship.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Gislaine Z. Réus
    • 1
  • Roberto B. Stringari
    • 1
  • Karine F. Ribeiro
    • 1
  • Andreza L. Cipriano
    • 1
  • Bruna S. Panizzutti
    • 2
  • Laura Stertz
    • 2
  • Camila Lersch
    • 2
  • Flávio Kapczinski
    • 2
  • João Quevedo
    • 1
  1. 1.Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da SaúdeUniversidade do Extremo Sul CatarinenseCriciúmaBrazil
  2. 2.Laboratório de Psiquiatria Molecular and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Centro de PesquisasHospital de Clínicas de Porto AlegrePorto AlegreBrazil

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