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Neurochemical Research

, Volume 35, Issue 10, pp 1487–1500 | Cite as

Proteomic Studies on the Development of the Central Nervous System and Beyond

  • Chenggang Zhang
Overview

Abstract

Neuroproteomics has become a ‘symbol’ or even a ‘sign’ for neuroscientists in the post-genomic era. During the last several decades, a number of proteomic approaches have been used widely to decipher the complexity of the brain, including the study of embryonic stages of human or non-human animal brain development. The use of proteomic techniques has allowed for great scientific advancements, including the quantitative analysis of proteomic data using 2D-DIGE, ICAT and iTRAQ. In addition, proteomic studies of the brain have expanded into fields such as subproteomics, synaptoproteomics, neural plasma membrane proteomics and even mitochondrial proteomics. The rapid progress that has been made in this field will not only increase the knowledge based on the neuroproteomics of the developing brain but also help to increase the understanding of human neurological diseases. This paper will focus on proteomic studies in the central nervous system and especially those conducted on the development of the brain in order to summarize the advances in this rapidly developing field.

Keywords

Proteomics Neuroproteomics Development Central nervous system 

Notes

Acknowledgments

We wish to thank the anonymous reviewers for their valuable suggestions for this manuscript. This work is supported by the National Basic Research Project (973 program) (2006CB504100), The National Key Technologies R&D Program for New Drugs (2009ZX09103-616, 2009ZX09503-002, 2009ZX09301-002), General Program (30900830, 30973107, 30800196, 30772293) of General Program of National Natural Science Foundation of China, Major Program for Science and Technology Research of Beijing Municipal Bureau (7061004).

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Beijing Institute of Radiation Medicine, State Key Laboratory of ProteomicsBeijingChina

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