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Neurochemical Research

, Volume 35, Issue 5, pp 743–748 | Cite as

High Affinity Carnitine Transporters from OCTN Family in Neural Cells

  • Elżbieta Januszewicz
  • Marek Bekisz
  • Jerzy W. Mozrzymas
  • Katarzyna A. Nałęcz
Original Paper

Abstract

Neurons are known to accumulate l-carnitine—a compound necessary for transfer of acyl moieties through biological membranes, apart from very low β-oxidation of fatty acids in adult brain. Present study demonstrates expression of octn2 and octn3 genes coding high affinity carnitine transporters, as well as presence of both proteins in neurons obtained from suckling and adult rats, and also in mouse transformed neural cells. Measurements of carnitine transport show activity of both transporters in neural cells, pointing to their importance in physiological processes other than β-oxidation.

Keywords

Carnitine OCTN transporters Neurons Cerebral cortex Neuroblastoma 

Notes

Acknowledgments

This work was financed by grants 0660/PO1/2006/30 and 0413/B/PO1/36 from the Polish Ministry of Science and Higher Education and statutory funds of the Nencki Institute.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Elżbieta Januszewicz
    • 1
  • Marek Bekisz
    • 1
  • Jerzy W. Mozrzymas
    • 2
  • Katarzyna A. Nałęcz
    • 1
  1. 1.Nencki Institute of Experimental BiologyWarsawPoland
  2. 2.Wrocław Medical UniversityWrocławPoland

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