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Neurochemical Research

, Volume 34, Issue 10, pp 1712–1720 | Cite as

Astrocytes and Interneurons in Memory Processing in the Chick Hippocampus: Roles for G-Coupled Protein Receptors, GABA(B) and mGluR1

  • Marie E. Gibbs
  • David N. Bowser
Original Paper

Abstract

Glutamate and GABA acting at mGluR1 and GABAB receptors, respectively, have roles in memory processing in the hippocampus up to 35 min after bead discrimination learning in the young chick. Activation of mGluR1 receptors is important at 2.5 and 30 min after training, but modulation of these receptors between these two times has no effect on memory. This timing is similar to the action of glutamate on NMDA receptors. The GABAB antagonist, phaclofen, and the inhibitor of astrocytic oxidative metabolism, fluoroacetate, inhibited memory when injected between 2.5 and 30 min. Paradoxically, a high dose of the GABAB agonist, baclofen, also inhibited memory, but a low dose promoted memory consolidation—an effect possibly caused by too much information and loss of the ‘message’. These results are interpreted in terms interactions between interneurons, astrocytes and pyramidal cells and demonstrate the importance of all cell types in memory processing in the hippocampus.

Keywords

GABA(B) mGluR Astrocytes Memory Chick Bead discrimination learning 

Notes

Acknowledgement

This work was funded by a Monash University Research Grant awarded to M. E. Gibbs.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Developmental BiologyMonash UniversityClaytonAustralia
  2. 2.Howard Florey and Mental Health Research InstitutesUniversity of MelbourneParkvilleAustralia
  3. 3.Department of Biochemistry and Molecular BiologyMonash UniversityClaytonAustralia

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