Neurochemical Research

, Volume 34, Issue 8, pp 1410–1416 | Cite as

Increased Receptor for Advanced Glycation Endproducts Immunocontent in the Cerebral Cortex of Vitamin A-Treated Rats

  • Marcos Roberto de OliveiraEmail author
  • Max William Soares Oliveira
  • Guilherme Antônio Behr
  • Matheus Augusto de Bittencourt Pasquali
  • José Cláudio Fonseca Moreira
Original Paper


Vitamin A, beyond its biological role, is an alternative choice in treating some life threatening pathologies, for instance leukemia and immunodeficiency. On the other hand, vitamin A therapy at moderate to high doses has caused concern among public health researchers due to the toxicological aspect resulting from such habit. It has been described hepatotoxicity, cognitive disturbances and increased mortality rates among subjects ingesting increased levels of vitamin A daily. Then, based on the previously reported data, we investigated here receptor for advanced glycation endproducts (RAGE) immunocontent and oxidative damage levels in cerebral cortex of vitamin A-treated rats at clinical doses (1,000–9,000 IU/kg day−1). RAGE immunocontent, as well as oxidative damage levels, were observed increased in cerebral cortex of vitamin A-treated rats. Whether increased RAGE levels exert negative effects during vitamin A supplementation it remains to be investigated, but it is very likely that deleterious consequences may arise from such alteration.


Vitamin A Cerebral cortex RAGE Oxidative stress 



This work was supported by grants of CNPq. M. R. de Oliveira, M. W. S. Oliveira, G. A. Behr, and M. A. B. Pasquali are recipients of a CNPq fellowship.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Marcos Roberto de Oliveira
    • 1
    Email author
  • Max William Soares Oliveira
    • 1
  • Guilherme Antônio Behr
    • 1
  • Matheus Augusto de Bittencourt Pasquali
    • 1
  • José Cláudio Fonseca Moreira
    • 1
  1. 1.Centro de Estudos em Estresse Oxidativo (Lab. 32), Departamento de Bioquímica, ICBSUniversidade Federal do Rio Grande do SulPorto AlegreBrazil

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