Neurochemical Research

, 34:2067

Cellular Elements of the Blood-Brain Barrier

Review Article

DOI: 10.1007/s11064-009-0081-y

Cite this article as:
Correale, J. & Villa, A. Neurochem Res (2009) 34: 2067. doi:10.1007/s11064-009-0081-y


The Blood-brain-barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), shielding the brain for toxic substances in the blood, supplying brain tissues with nutrients and filtering harmful compounds from the brain back to the bloodstream. The BBB is composed of four main cellular elements: endothelial cells (ECs), astrocyte end-feet, microglial cells, and perycites. Transport across the BBB is limited by both physical and metabolic barriers (enzymes, and different transport systems). Tight junctions (TJs) present between ECs form an important barrier against diffusion, excluding most blood-borne substances for entering the brain.


Blood brain barrier Transport Endothelial cells Astrocytes Perycites Basement membrane matrix 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of NeurologyInstitute for Neurological Research Dr. Raúl Carrea (FLENI)Buenos AiresArgentina
  2. 2.School of Biomedical SciencesAustral UniversityBuenos AiresArgentina
  3. 3.Department of Neurology, José María Ramos Mejía HospitalSchool of Medicine Buenos Aires UniversityBuenos AiresArgentina

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