Neurochemical Research

, Volume 35, Issue 1, pp 171–179

Neurotoxic Effects of Methamphetamine

  • Bessy Thrash
  • Senthilkumar S. Karuppagounder
  • Subramaniam Uthayathas
  • Vishnu Suppiramaniam
  • Muralikrishnan Dhanasekaran
Original Paper

Abstract

In Parkinson’s disease, depletion of dopamine in the striatum leads to various symptoms such as tremor, rigidity and akinesia. Methamphetamine use has significantly increased in USA and around the world and there are several reports showing that its long-term use increases the risk for dopamine depletion. However, the toxic mechanisms of methamphetamine are not well understood. This study was undertaken to gain greater mechanistic understanding of the toxicity induced by methamphetamine. We evaluated the effect of methamphetamine on the generation of reactive oxygen species, mitochondrial monoamine oxidase, complex I & IV activities. Behavioral analysis evaluated the effect on catalepsy, akinesia and swim score. Neurotransmitter levels were evaluated using high pressure liquid chromatography (HPLC) electrochemical detection (ECD). Results showed that methamphetamine caused significant generation of reactive oxygen species and decreased complex I activity in the mitochondria leading to dopamine depletion in the striatum.

Keywords

Methamphetamine Neurotoxicity Parkinson’s disease Oxidative stress Dopamine Behavior 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Bessy Thrash
    • 1
  • Senthilkumar S. Karuppagounder
    • 1
  • Subramaniam Uthayathas
    • 1
  • Vishnu Suppiramaniam
    • 1
  • Muralikrishnan Dhanasekaran
    • 1
  1. 1.Department of Pharmacal Sciences, Harrison School of PharmacyAuburn UniversityAuburnUSA

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