Neurochemical Research

, Volume 33, Issue 10, pp 1979–1989 | Cite as

Characteristics of HCN Channels and Their Participation in Neuropathic Pain

Original Paper


Neuropathic pain is induced by the injury to nervous systems and characterized by hyperalgesia, allodynia and spontaneous pain. The underlying mechanisms include peripheral and central sensitization resulted from neuronal hyperexcitability. A number of ion channels are considered to contribute to the neuronal hyperexcitability. Here, we particularly concentrate on an interesting ion channel, hyperpolarization-activated cyclic nucleotide gated (HCN) channels. We overview its biophysical properties, physiological functions, followed by focusing on the current progress in the study of its role in the development of neuropathic pain. We attempt to provide a comprehensive review of the potential valuable target, HCN channels, in the treatment of neuropathic pain.


Hyperpolarization-activated cyclic nucleotide gated cation channels (HCN) Ih Neuropathic pain Ectopic discharges Peripheral sensitization ZD7288 



This work was supported by the grants from Beijing Natural Science Foundation (7052039), National Natural Science Foundation of China (30600173, 30570566, 30470559 and 30330230), “111” Project of the Ministry of Education of China and “973” program of the Ministry of Science and Technology of China (2007CB512501).


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Yu-Qiu Jiang
    • 1
    • 2
  • Qian Sun
    • 1
    • 3
  • Hui-Yin Tu
    • 1
    • 4
  • You Wan
    • 1
    • 2
    • 5
  1. 1.Neuroscience Research InstitutePeking UniversityBeijingPeople’s Republic of China
  2. 2.Department of NeurobiologyPeking UniversityBeijingPeople’s Republic of China
  3. 3.Department of BiologyBrandeis UniversityWalthamUSA
  4. 4.Department of PhysiologyBasic Medical College of Zhengzhou UniversityZhengzhouPeople’s Republic of China
  5. 5.Key Laboratory for NeurosciencePeking UniversityBeijingPeople’s Republic of China

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