Neurochemical Research

, Volume 33, Issue 12, pp 2427–2435 | Cite as

Regulation and Function of Cyclic GMP-Mediated Pathways in Glial Cells

  • María Antonia Baltrons
  • Mariela Susana Borán
  • Paula Pifarré
  • Agustina García
Original Paper


A large body of evidence supports a role for the NO-cGMP-protein kinase G pathway in the regulation of synaptic transmission and plasticity, brain development and neuroprotection. Circumstancial evidence implicates natriuretic peptide-stimulated cGMP formation in the same CNS functions. In addition to neurons, both cGMP-mediated pathways are functional in glial cells and an increasing number of reports indicate that they may control important aspects of glial cell physiology relevant to neuronal function. In this article we briefly review the regulation of cGMP formation in glial cells and summarize recent evidence indicating that cGMP-mediated pathways can play important roles in astroglial and microglial function in normal and diseased brain.


Astrocytes Cell migration Cytokines Cytoskeleton cGMP Guanylyl cyclase Lipopolysaccharide Microglia Natriuretic peptides Neuroinflammation Nitric oxide synthase Phagocytosis Reactive gliosis Rho GTPases 



This work was supported by grants from Ministerio de Educación y Ciencia (MEC), Spain (SAF2004-01717) and Direcció General de Recerca (DGR), Generalitat de Catalunya (SGR2005-939) to AG. MSB and PP were recipients of predoctoral fellowships from DGR and MEC, respectively.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • María Antonia Baltrons
    • 1
  • Mariela Susana Borán
    • 1
  • Paula Pifarré
    • 1
  • Agustina García
    • 1
  1. 1.Institute of Biotechnology and Biomedicine ‘V. Villar Palasí’ and Departament of Biochemistry and Molecular BiologyUniversitat Autònoma de BarcelonaBellaterraSpain

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