Neurochemical Research

, Volume 33, Issue 5, pp 729–736

The Effect of n-acetylcysteine and Deferoxamine on Exercise-induced Oxidative Damage in Striatum and Hippocampus of Mice

  • Aderbal S. AguiarJr
  • Talita Tuon
  • Fernanda S. Soares
  • Luís Gustavo C. da Rocha
  • Paulo César Silveira
  • Ricardo A. Pinho
Original Paper


The aim of this study was to analyze the effects of intense exercise on brain redox status, associated with antioxidant supplementation of N-acetylcysteine (NAC), deferoxamine (DFX) or a combination of both. Seventy-two C57BL-6 adult male mice were randomly assigned to 8 groups: control, NAC, DFX, NAC plus DFX, exercise, exercise with NAC, exercise with DFX, and exercise with NAC plus DFX. They were given antioxidant supplementation, exercise training on a treadmill for 12 weeks, and sacrificed 48 h after the last exercise session. Training significantly increased (P < 0.05) soleus citrate synthase (CS) activity when compared to control. Blood lactate levels classified the exercise as intense. Exercise significantly increased (P < 0.05) oxidation of biomolecules and superoxide dismutase activity in striatum and hippocampus. Training significantly increased (P < 0.05) catalase activity in striatum. NAC and DFX supplementation significantly protected (P < 0.05) against oxidative damage. These results indicate intense exercise as oxidant and NAC and DFX as antioxidant to the hippocampus and the striatum.


Physical exercise Oxidative stress Striatum Hippocampus n-acetylcysteine Deferoxamine 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Aderbal S. AguiarJr
    • 1
  • Talita Tuon
    • 1
  • Fernanda S. Soares
    • 1
  • Luís Gustavo C. da Rocha
    • 1
  • Paulo César Silveira
    • 1
  • Ricardo A. Pinho
    • 1
  1. 1.Laboratory of Exercise Physiology, PPGCSUniversidade do Extremo Sul CatarinenseCriciumaBrazil

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