Relation of Plasma Homocysteine to Plasma Amyloid Beta Levels
Elevated plasma homocysteine and amyloid β (Aβ) have been associated with Alzheimer’s disease (AD). We investigated the cross-sectional association between these biomarkers.
We used linear regression to relate plasma homocysteine and Aβ adjusting for age, gender, creatinine, APOE-ε4, and ethnic group in 327 persons aged 78 ± 6.6 years.
Plasma homocysteine correlated with age, serum creatinine, plasma Aβ40 and Aβ42, and was inversely correlated with serum vitamin B12, and folate. Aβ42, but not Aβ40, was related to later development of dementia. Homocysteine was related to higher Aβ40 levels (coefficient = 2.0; P < 0.0001) and this association was attenuated after adjustment for creatinine (coefficient = 1.0; P < 0.0001). The crude association between homocysteine and Aβ42 was weaker (coefficient = 0.5; P = 0.01) and became non-significant after adjustment for creatinine (coefficient = 0.4; P = 0.06). These associations were unrelated to ethnicity, the presence of APOE-ε4 or dementia. Analyses by quartiles of homocysteine showed that these association were driven primarily by the fourth quartile.
Plasma homocysteine is directly related to Aβ40. The association with Aβ42 is not significant. These results seem to indicate that homocysteine is related to aging but not specifically to AD.
KeywordsHomocysteine Plasma Amyloid beta Alzheimer’s disease
Support for this work was provided by grants from the National Institutes of Health AG15294, AG07232, AG07702, AG20856, RR00645 from the Charles S. Robertson Memorial Gift for research on Alzheimer’s disease, and from the Blanchette Hooker Rockefeller Foundation.
- 3.Budge MM, de Jager C, Hogervorst E, Smith AD, Oxford Project To Investigate Memory and Ageing (2002) Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older people. J Am Geriatr Soc 50:2014–2018Google Scholar
- 18.Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (1994) American Psychiatric Association, Washington, DC, pp 143–147Google Scholar
- 25.Fleiss JL (1981) Statistical methods for rates and proportions, 2nd edn. Joseph Wiley and SonsGoogle Scholar