Neurochemical Research

, Volume 32, Issue 4–5, pp 775–781

Relation of Plasma Homocysteine to Plasma Amyloid Beta Levels

  • José A. Luchsinger
  • Ming-Xin Tang
  • Joshua Miller
  • Ralph Green
  • Pankash D. Mehta
  • Richard Mayeux
Original Paper

Abstract

Background

Elevated plasma homocysteine and amyloid β (Aβ) have been associated with Alzheimer’s disease (AD). We investigated the cross-sectional association between these biomarkers.

Methods

We used linear regression to relate plasma homocysteine and Aβ adjusting for age, gender, creatinine, APOE-ε4, and ethnic group in 327 persons aged 78 ± 6.6 years.

Results

Plasma homocysteine correlated with age, serum creatinine, plasma Aβ40 and Aβ42, and was inversely correlated with serum vitamin B12, and folate. Aβ42, but not Aβ40, was related to later development of dementia. Homocysteine was related to higher Aβ40 levels (coefficient = 2.0; P < 0.0001) and this association was attenuated after adjustment for creatinine (coefficient = 1.0; P < 0.0001). The crude association between homocysteine and Aβ42 was weaker (coefficient = 0.5; P = 0.01) and became non-significant after adjustment for creatinine (coefficient = 0.4; P = 0.06). These associations were unrelated to ethnicity, the presence of APOE-ε4 or dementia. Analyses by quartiles of homocysteine showed that these association were driven primarily by the fourth quartile.

Conclusions

Plasma homocysteine is directly related to Aβ40. The association with Aβ42 is not significant. These results seem to indicate that homocysteine is related to aging but not specifically to AD.

Keywords

Homocysteine Plasma Amyloid beta Alzheimer’s disease 

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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • José A. Luchsinger
    • 1
    • 2
  • Ming-Xin Tang
    • 1
    • 3
  • Joshua Miller
    • 5
  • Ralph Green
    • 5
  • Pankash D. Mehta
    • 9
  • Richard Mayeux
    • 1
    • 4
    • 6
    • 7
    • 8
  1. 1.Taub Institute for Research of Alzheimer’s Disease and the Aging BrainColumbia UniversityNew YorkUSA
  2. 2.Division of General Medicine, Department of MedicineColumbia University College of Physicians and SurgeonsNew YorkUSA
  3. 3.Division of Biostatistics, Joseph P. Mailman School of Public HealthColumbia UniversityNew YorkUSA
  4. 4.Division of Epidemiology, Joseph P. Mailman School of Public HealthColumbia UniversityNew YorkUSA
  5. 5.Department of Medical Pathology, School of MedicineUniversity of CaliforniaDavisUSA
  6. 6.Gertrude H. Sergievsky CenterColumbia UniversityNew YorkUSA
  7. 7.Department of NeurologyColumbia University College of Physicians and SurgeonsNew YorkUSA
  8. 8.Department of PsychiatryColumbia University College of Physicians and SurgeonsNew YorkUSA
  9. 9.Department of ImmunologyInstitute for Basic Research in Developmental DisabilitiesStaten IslandUSA

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