Neurochemical Research

, Volume 32, Issue 2, pp 187–195 | Cite as

Microtubule Deacetylases, SirT2 and HDAC6, in the Nervous System

  • Cherie M. Southwood
  • Marcello Peppi
  • Sylvia Dryden
  • Michael A. Tainsky
  • Alexander Gow
ORIGINAL PAPER

Abstract

Examination of the cytoskeleton has demonstrated the pivotal role of regulatory proteins governing cytoskeletal dynamics. Most work has focused on cell cycle and cell migration regarding cancer. However, these studies have yielded tremendous insight for development, particularly in the nervous system where all major cell types remodel their shape, generate unsurpassed quantities of membranes and extend cellular processes to communicate, and regulate the activities of other cells. Herein, we analyze two microtubule regulatory alpha-tubulin deacetylases, histone deacetylase-6 (HDAC6) and SirT2. HDAC6 is expressed by most neurons but is abundant in cerebellar Purkinje cells. In contrast, SirT2 is targeted to myelin sheaths. Expression of these proteins by post-mitotic cells indicates novel functions, such as process outgrowth and membrane remodeling. In oligodendrocytes, targeting of SirT2 to paranodes coincides with the presence of the microtubule-destabilizing protein stathmin-1 during early myelinogenesis and suggests the existence of a microtubule regulatory network that modulates cytoskeletal dynamics.

Keywords

Axoglial junctions Myelinated fibers Central nervous system Peripheral nervous system Immunofluorescence Mouse 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Cherie M. Southwood
    • 1
  • Marcello Peppi
    • 1
  • Sylvia Dryden
    • 2
  • Michael A. Tainsky
    • 1
    • 2
    • 3
  • Alexander Gow
    • 1
    • 4
    • 5
  1. 1.Center for Molecular Medicine and GeneticsWayne State University School of MedicineDetroitUSA
  2. 2.Karmanos Cancer CenterWayne State University School of MedicineDetroitUSA
  3. 3.Department of PathologyWayne State University School of MedicineDetroitUSA
  4. 4.Carman and Ann Adams Department of PediatricsWayne State University School of MedicineDetroitUSA
  5. 5.Department of NeurologyWayne State University School of MedicineDetroitUSA

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