Neurochemical Research

, Volume 31, Issue 5, pp 699–703

Changes in Antioxidant Defense Enzymes after d-amphetamine Exposure: Implications as an Animal Model of Mania

  • Benício N. Frey
  • Samira S. Valvassori
  • Gislaine Z. Réus
  • Márcio R. Martins
  • Fabrícia C. Petronilho
  • Katrine Bardini
  • Felipe Dal-Pizzol
  • Flávio Kapczinski
  • João Quevedo
ORIGINAL PAPER

Abstract

Studies have demonstrated that oxidative stress is associated with amphetamine-induced neurotoxicity, but little is known about the adaptations of antioxidant enzymes in the brain after amphetamine exposure. We studied the effects of acute and chronic amphetamine administration on superoxide dismutase (SOD) and catalase (CAT) activity, in a rodent model of mania. Male Wistar rats received either a single IP injection of d-amphetamine (1 mg/kg, 2 mg/kg, or 4 mg/kg) or vehicle (acute treatment). In the chronic treatment rats received a daily IP injection of either d-amphetamine (1 mg/kg, 2 mg/kg, or 4 mg/kg) or vehicle for 7 days. Locomotor behavior was assessed using the open field test. SOD and CAT activities were measured in the prefrontal cortex, hippocampus, and striatum. Acute and to a greater extent chronic amphetamine treatment increased locomotor behavior and affected SOD and CAT activities in the prefrontal cortex, hippocampus and striatum. Our findings suggest that amphetamine exposure is associated with an imbalance between SOD and CAT activity in the prefrontal cortex, hippocampus and striatum.

Keywords

Animal model Amphetamine Bipolar disorder Catalase Oxidative stress Superoxide dismutase 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Benício N. Frey
    • 1
    • 2
    • 3
  • Samira S. Valvassori
    • 4
  • Gislaine Z. Réus
    • 4
  • Márcio R. Martins
    • 4
  • Fabrícia C. Petronilho
    • 5
  • Katrine Bardini
    • 5
  • Felipe Dal-Pizzol
    • 5
  • Flávio Kapczinski
    • 1
    • 2
  • João Quevedo
    • 4
  1. 1.Departamento de BioquímicaInstituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulPorto AlegreBrazil
  2. 2.Bipolar Disorders ProgramHospital de Clínicas de Porto AlegrePorto AlegreBrazil
  3. 3.MOOD-CNS Program, Division of Mood and Anxiety Disorders, Department of PsychiatryThe University of Texas Health Science Center at San AntonioSan AntonioUSA
  4. 4.Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da SaúdeUniversidade do Extremo Sul CatarinenseCriciúmaBrazil
  5. 5.Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da SaúdeUniversidade do Extremo Sul CatarinenseCriciúmaBrazil

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