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Neurochemical Research

, Volume 30, Issue 12, pp 1615–1621 | Cite as

Taurine Interaction with Neurotransmitter Receptors in the CNS: An Update

  • Jan AlbrechtEmail author
  • Arne Schousboe
Article

Abstract

Taurine appears to have multiple functions in the brain participating both in volume regulation and neurotransmission. In the latter context it may exert its actions by serving as an agonist at receptors of the GABAergic and glycinergic neurotransmitter systems. Its interaction with GABAA and GABAB receptors as well as with glycine receptors is reviewed and the physiological relevance of such interactions is evaluated. The question as to whether local extracellular concentrations of taurine are likely to reach the threshold level for the pertinent receptor populations cannot presently be answered satisfactorily. Hence more sophisticated analytical methods are warranted in order to obtain a definite answer to this important question.

Key words

Taurine GABAA receptor GABAB receptor glycine receptor 

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© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Department of NeurotoxicologyMedical Research Centre, Polish Academy of SciencesWarsawPoland
  2. 2.Department of Pharmacology and PharmacotherapyThe Danish University of Pharmaceutical SciencesDenmark

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