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Neurochemical Research

, 30:1227 | Cite as

Ependymal Cell Differentiation and GLUT1 Expression is a Synchronous Process in the Ventricular Wall

  • Carmen Silva-AlvarezEmail author
  • Mónica Carrasco
  • Carolina Balmaceda-Aguilera
  • Patricia Pastor
  • María de los Angeles García
  • Karin Reinicke
  • Luis Aguayo
  • Benedicto Molina
  • Manuel Cifuentes
  • Rodolfo Medina
  • Francisco Nualart
Article

Abstract

Ependymal cells appear to be totally differentiated during the first 3 weeks in the mouse brain. Early during postnatal development ependymal cells differentiate and undergo metabolic activation, which is accompanied by increased glucose uptake. We propose that ependymal cells induce an overexpression of the glucose transporter, GLUT1, during the first 2 weeks after delivery in order to maintain the early metabolic activation. During the first postnatal day, GLUT1 is strongly induced in the upper region of the third ventricle and in the ventral area of the rostral cerebral aqueduct. During the next 4 days, GLUT1 is expressed in all differentiated ependymal cells of the third ventricle and in hypothalamic tanycytes. At the end of the first week, ependymal cell differentiation and GLUT1 overexpression is concentrated in the latero-ventral area of the aqueduct. We propose that ependymal cell differentiation and GLUT1 overexpression is a synchronous process in the ventricular wall.

Keywords

Cerebral aqueduct ependymal cells GLUT1 ventricular zone, SCO 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Carmen Silva-Alvarez
    • 1
    Email author
  • Mónica Carrasco
    • 1
  • Carolina Balmaceda-Aguilera
    • 1
  • Patricia Pastor
    • 1
  • María de los Angeles García
    • 1
  • Karin Reinicke
    • 1
  • Luis Aguayo
    • 2
  • Benedicto Molina
    • 3
  • Manuel Cifuentes
    • 4
  • Rodolfo Medina
    • 5
  • Francisco Nualart
    • 1
  1. 1.Laboratorio de Neurobiología Celular, Departamento de Biología Celular Facultad de Ciencias BiológicasUniversidad de ConcepciónConcepciónChile
  2. 2.Departamento de Fisiología, Facultad de Ciencias BiológicasUniversidad de ConcepciónConcepciónChile
  3. 3.Departamento de Ciencias Básicas, Facultad de MedicinaUniversidad de La FronteraTemucoChile
  4. 4.Departamento de Biología Celular, Genética y Fisiología, Facultad de CienciasUniversidad de MálagaMálagaSpain
  5. 5.Department of Basic Medical Sciences, St. George’sUniversity of LondonLondonUK

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