Neurochemical Research

, Volume 30, Issue 5, pp 619–624 | Cite as

Effect of Toluene and Nutritional Status on Serotonin, Lipid Peroxidation Levels and NA+/K+-ATPase in Adult Rat Brain

  • David Calderón-Guzmán
  • Ivonne Espitia-Vázquez
  • Alejandra López-Domínguez
  • Ernestina Hernández-García
  • Bernardino Huerta-Gertrudis
  • Elvia Coballase-Urritia
  • Hugo Juárez-Olguín
  • Beatriz García-Fernández
Article
Accepted:

Abstract

The aim was to evaluate the effect of toluene and nutritional status on levels of serotonin (5-HT), 5-hydroxytryptophan (5-HTP), Na+/K+-ATPase, total ATPase and lipid peroxidation (TBARS) in rat brain. Study was conducted with malnourished (MN), well-nourished (WN) and normal Wistar rats. Three groups were formed for each nutritional status: control group I received 0.9% NaCl; toluene (1 g/kg) was administered to group II, and 1.5 g/kg to group III. Levels of 5-HT decreased (P < 0.05) in WN toluene groups, and 5-HTP decreased (P < 0.05) in the WN 1 g toluene and MN 1.5 g toluene groups. TBARS decreased (P < 0.05) in WN toluene groups. A trend to increase in Na+/K+-ATPase was found in WN and MN toluene groups, while total ATPase increased (P < 0.05) in the WN 1.5 g toluene group. The results suggest that high concentrations of toluene in single doses induce significant changes in the serotonergic system and alter membrane fluidity more perceptibly in the brain of adult animals with regular diet than in malnourished animals.

Key words

5-Hydroxytryptophan lipid peroxidation nutritional status serotonin toluene 
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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • David Calderón-Guzmán
    • 1
    • 2
  • Ivonne Espitia-Vázquez
    • 1
  • Alejandra López-Domínguez
    • 1
    • 5
  • Ernestina Hernández-García
    • 2
  • Bernardino Huerta-Gertrudis
    • 1
  • Elvia Coballase-Urritia
    • 3
  • Hugo Juárez-Olguín
    • 2
    • 4
  • Beatriz García-Fernández
    • 5
  1. 1.Laboratorio de NeuroquímicaInstituto Nacional de Pediatría (INP)México
  2. 2.Laboratorio de FarmacologíaInstituto Nacional de Pedíatria Mexico CityMéxico
  3. 3.Laboratorio de BacteriologíaINPMéxico
  4. 4.Departamento de Farmacología, Facultad de MedicinaUniversidad Nacional Autónoma deMéxico
  5. 5.Departamento de Sistemas BiológicosUniversidad Autónoma Metropolitana-XochimilcoMéxico

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