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Neurochemical Research

, Volume 30, Issue 2, pp 185–190 | Cite as

Short- and Long-term Memory are Differentialy Modulated by Hippocampal Nerve Growth Factor and Fibroblast Growth Factor

  • Roger Walz
  • Rafael Roesler
  • Adalisa Reinke
  • Márcio Rodrigo Martins
  • João QuevedoEmail author
  • Ivan Izquierdo
Article

Rats were implanted with cannulae in the CA1 area of the dorsal hippocampus and trained in one-trial step-down inhibitory avoidance. Two retention tests were carried out in each animal, one at 1.5 h to measure short-term memory (STM) and another at 24 h to measure long-term memory (LTM). The purpose of the present study was to evaluate the modulation on hippocampal nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) on short- and long-term memory. Immediately after training, animals received 5 μl of NGF (0.05, 0.5 or 5.0 ng), bFGF (1.25, 12.5 or 125 ng) or saline per side. At the higher dose, NGF blocked STM. In contrast, NGF at dose of 0.5 and 5.0 ng improved LTM. The bFGF infusion at a dose of 125 ng enhanced LTM. However, bFGF did not alter STM. These findings indicate that hippocampal NGF and bFGF modulate STM and LTM in a different manner.

KEY WORDSL

NGF FGF memory consolidation rat 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Roger Walz
    • 1
  • Rafael Roesler
    • 2
  • Adalisa Reinke
    • 3
  • Márcio Rodrigo Martins
    • 3
  • João Quevedo
    • 3
    • 4
    Email author
  • Ivan Izquierdo
    • 4
  1. 1.Departamento de MedicinaUniversidade do Vale do ItajaíItajaíBrazil
  2. 2.Laboratório de Neurofarmacologia Pré-Clínica, Departamento de FarmacologiaInstituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulPorta AlegreBrazil
  3. 3.Laboratório de NeurociênciasUniversidade do Extremo Sul CatarinenseCriciúmaBrazil
  4. 4.Centro de Memória, Departamento de BioquímicaInstituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do SulPorto AlegreBrazil

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