Effects of Neonatal Administration of Memantine on Hippocampal Asymmetry and Working Memory Impairment Induced by Early Maternal Deprivation in Rats
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Schizophrenia is manifested with abnormalities in working memory and in exaggerated asymmetry of the hippocampus, basal ganglia, and temporoparietal cortex. Using an early maternal deprivation model, we evaluated brain histology and working memory at childhood, adolescence, and adulthood of the experimental animals. Incorrect patterns of brain asymmetry, which involved the striatum in childhood and adolescence and the hippocampus in adulthood were associated with clear working memory deficit. Neonatal treatment with memantine (10 mg/kg) could prevent those changes effectively. These results raise the possibility that pharmacological treatment with MEM within early developmental stages can help people with a risk to develop schizophrenia.
Keywordsmaternal deprivation model schizophrenia NMDA glutamate striatum hippocampus development
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- 12.E. Uribe and R. Wix, “Conexión sináptica y esquizofrenia,” Neurocien. Colom., 18, 258–271 (2011).Google Scholar
- 13.E. Uribe and R. Wix, “Migración neuronal y esquizofrenia,” Neurocien. Colom., 17, 45–60 (2010).Google Scholar
- 15.D. Mier and P. Kirsch, “Social-cognitive deficits in schizophrenia,” Curr. Top. Behav. Neurosci., 3, 397–409 (2016).Google Scholar
- 18.Institute of Laboratory Animal Resources, Guide for the Care and Use of Laboratory Animals, Natl. Acad. Press, Washington, D.C. USA (2011).Google Scholar
- 19.B. Cabuk, V. Etus, S. U. Bozkurt, et al., “Neuroprotective effect of memantine on hippocampal neurons in infantile rat hydrocephalus,” Turk. Neurosurg., 21, 352–358 (2011).Google Scholar
- 23.E. Uribe and R. Wix, “Epigenetic control of the GABAergic interneurons migration and NMDA receptor functioning in schizophrenia,” eNeurobiología, 2, 1–13 (2011).Google Scholar
- 38.E. Uribe, “Neuropsychological subtypes of schizophrenia and prefrontal circuits,” eNeurobiología., 7, 280516 (2016).Google Scholar
- 39.Y. Huang, A. Matysiak, P. Heil, et al., “Persistent neural activity in auditory cortex is related to auditory working memory in humans and nonhuman primates,” Elife, 20, 5. pii: e15441 (2016).Google Scholar
- 43.E. Uribe, L. Fernandez, D. Pacheco, et al., “Administration of memantine reverses behavioral, histological, and electrophysiological abnormalities in rats subjected to early maternal deprivation,” J. Neural Transm. (Vienna), 126, No. 6, 759–770 (2019).Google Scholar
- 45.S. J. Arnold, E. I. Ivleva, T. A. Gopal, et al., “Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar I disorder demonstrated by both manual tracing and automated parcellation (Free Surfer),” Schizophr. Bull., 41, 233–249 (2015).CrossRefGoogle Scholar
- 50.C. J. Herold, M. M. Lässer, L. A. Schmid, et al., “Neuropsychology, autobiographical memory, and hippocampal volume in “younger” and “older” patients with chronic schizophrenia,” Front. Psychiatry, 21, 6–53 (2015).Google Scholar