Cerebrospinal Fluid Levels of Interleukin-17 and Interleukin-34 in Patients with Neuro-Behcet’s Syndrome
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Behcet’s disease (BD) is a rather rare chronic multisystemic vasculitic disease. Clear neurological involvement is observed in up to 49% of patients with BD. Cytokines play a pivotal role in the pathogenesis of BD. Data on the cerebrospinal fluid (CSF) levels of cytokines in patients with Neuro-Behcet’s disease (NBD) are limited. We measured the CSF levels of Interleukin (IL)-17A, IL-17F, and IL-34 in 7 patients with NBD (median age of 38 years). Eleven control subjects were of a median age of 42 years. There was no significant difference in the male-to-female ratio and age between the NBD and control groups (P > 0.05). There was also no significant difference in biochemical values of CSF between NBD patients and control subjects. The CSF levels of IL-17 was significantly higher in patients with active NBD compared to the control (P < 0.05), whereas the CSF levels of IL-34 showed no difference compared to the control group (P > 0.05). This is the first study investigating the CSF levels of IL-34 in patients with NBD. Further studies with a larger sample size are required to confirm the role and values of the IL-34 levels in NBD.
Keywordsneuro-Behcet’s syndrome cerebrospinal fluid cytokines interleukins IL-17 IL-34
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- 1.D. Ciliz, B. Sakman, E. Fettahoǧlu, and E. Yuksel, “Nöro-Behçet hastalıǧında kranyal MRG bulguları,” Tanısal ve Girisimsel Radyoloji , 7, 452–459 (2001).Google Scholar
- 6.U. Gangishetti, J. C. Howell, A. Kollhoff, and W. Hu, CSF Cytokine Profiles Uniquely Identify Different Neurodegenerative Disorders (P4. 175), AAN Enterprises (2018).Google Scholar
- 9.P. Miossec, “Update on interleukin-17: a role in the pathogenesis of inflammatory arthritis and implication for clinical practice,” RMD Open, 3, No. 1, e000284 (2017).Google Scholar
- 13.[No authors listed], “Criteria for diagnosis of Behçet’s disease. International study group for Behçet’s disease,” Lancet, 335, No. 8697, 1078–1080 (1990).Google Scholar
- 14.D. I. Friedman, G. T. Liu, and K. B. Digre, “Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children,” Neurology, 81, No. 13, 1159–1165 (2013).Google Scholar
- 17.K. Hamzaoui, W. Kaabachi, B. Fazaa, et al., “Serum IL-33 levels and skin mRNA expression in Behçet’s disease,” Clin. Exp. Rheumatol., 31, No. 3, Suppl. 77, 6–14 (2013).Google Scholar
- 21.S. Na, M. Park, S. Park, and E. Lee, “Up-regulation of Th17 and related cytokines in Behçet’s disease corresponding to disease activity,” Clin. Exp. Rheumatol., 31, No. 3, Suppl 77, 32–40 (2013).Google Scholar