, Volume 51, Issue 2, pp 66–71 | Cite as

Aerobic Physical Training Protects the Rat Brain Against Exercise-Heat Related Oxidative Damage through the Increased Expression of HSP70

  • D. Wang
  • J. W. Ripley-Gonzalez
  • Y. HuEmail author

We explored the mechanism underlying the improvement of tolerance to exercise-heat stress through physical training at a moderate temperature. Rats were randomly divided into an aerobic exercise (AE) group and a control (C) group. Rats in the former group were subjected during 5 weeks for AE in a cool environment (20°C). The oxidative damage level in the brain to AE rats after both 1-h-long heat exposure and exhaustive exercise in heat and the rate of core temperature rise were lower than those in the control (P < 0.05). The expression level of HSP70 in the motor cortex and the exhaustion time in group AE were found to be significantly greater compared to those in group C (P < 0.05). Our results indicate that the enhanced expression of HSP70 may be an important factor for physical training in a cool environment, and this factor improves tolerance to exercise-heat stress.


aerobic physical training oxidative damage brain temperature conditions exercise-heat stress HSP70 


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Physical EducationNational University of Defense TechnologyChangshaChina
  2. 2.Foreign Affairs OfficeNational University of Defense TechnologyChangshaChina
  3. 3.Department of Physical EducationCentral South UniversityChangshaChina

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