A Physiological/Model Study on the Effects of Deep Breathing on the Respiration Rate, Oxygen Saturation, and Cerebral Oxygen Delivery in Humans

  • K. S. Cheng
  • P. F. LeeEmail author

There are limited reports on using a mathematical approach to relate the respiration rate with the cerebrovascular flow rate during and after periods of deep breathing (DB) in humans. Here, modeling was applied to estimate the cerebral oxygen delivery (CDO2) impacted by three episodes of DB of different durations on a few parameters, including the respiration rate (RF) and oxygen saturation (SpO2). Results indicated that the DB groups of tested subjects achieved a qualitatively lower RF and greater CDO2 during the follow-up session. This suggests that the constant practice of deep breathing leads to a reduction in the RF and an increment in the CDO2, which can potentially improve cognitive abilitiy.


cerebral oxygen delivery deep breathing episodes respiration rate oxygen saturation 


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  1. 1.
    J. West, Pulmonary Pathophysiology: the Essentials, Wolters Kuwer/Lippincott Williams and Wilkins Health, Philadelphia (2013).Google Scholar
  2. 2.
    J. Jongbloed, C. L. C. van Nieuwenhuizen, and H. van Goor, “A heart function test with continuous registration of oxygen consumption and carbon dioxide production,” Circulation, 15, 54-63 (1957).CrossRefGoogle Scholar
  3. 3.
    P. J. Eames, J. F. Potter, and R. B. Panerai, “Influence of controlled breathing patterns on cerebrovascular autoregulation and cardiac baroreceptor sensitivity,” Clin. Sci., 106, 155-162 (2004).CrossRefGoogle Scholar
  4. 4.
    S. J. E. Lucas, N. C. S. Lewis, E. L. G. Sikken, et al., “Slow breathing as a means to improve orthostatic tolerance : a randomized sham-controlled trial,” J. Appl. Physiol., 115, 202-211 (2013).CrossRefGoogle Scholar
  5. 5.
    W. Karlen, H. Gan , M. Chiu, et al., “Improving the accuracy and efficiency of respiratory rate measurements in children using mobile devices,” PLoS One, 9, 1-9 (2014).Google Scholar
  6. 6.
    J. W. Severinghaus, “Simple, accurate equations for human blood O2 dissociation computations,” J. Appl. Physiol., 46, 599-602 (1979).CrossRefGoogle Scholar
  7. 7.
    R. O. Crapo, R. L. Jensen, M. Hegewald, and D. P. Tashkin, “Arterial blood gas reference values for sea level and an altitude of 1,400 meters,” Am. J. Respir. Crit. Care Med., 160, 1525-1531 (1999).CrossRefGoogle Scholar
  8. 8.
    S. K. Piechnik, P. A. Chiarelli, and P. Jezzard, “Modelling vascular reactivity to investigate the basis of the relationship between cerebral blood volume and flow under CO2 manipulation,” NeuroImage, 39, 107-118 (2008).CrossRefGoogle Scholar
  9. 9.
    R. Lampe, N. Botkin, V. Turova, et al., “Mathematical modelling of cerebral blood circulation and cerebral autoregulation: towards preventing intracranial hemorrhages in preterm newborns,” Comput. Math. Methods Med., 2014, 1-9 (2014).CrossRefGoogle Scholar
  10. 10.
    R. MecPherson and M. Pincus, Henry’s Clinical Diagnosis and Management by Laboratory Methods, Saunders (2011).Google Scholar
  11. 11.
    E. Tharion, P. Samuel, R. Rajalakshmi, et al., “Influence of deep breathing exercise on spontaneous respiratory rate and heart rate variability: a randomised controlled trial in healthy subjects,” Indian J. Physiol. Pharmacol., 56, 80-87 (2012).Google Scholar
  12. 12.
    G. Bilo, M. Revera, M Bussotti, et al., “Effects of slow deep breathing at high altitude on oxygen saturation, pulmonary and systemic hemodynamics,” PLoS One, 7, 1-7 (2012).CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Lee Kong Chien Faculty of Engineering and ScienceUniversity TunkuSelangorMalaysia

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