Advertisement

Neurophysiology

, Volume 44, Issue 5, pp 409–413 | Cite as

Behavioral Effects of Physical Exercise and Exogenous Testosterone in Male Rats

  • J. Hodosy
  • D. Ostatníková
  • M Kúdela
  • P. CelecEmail author
Article
  • 89 Downloads

The aim of our study was to analyze the interrelation between the effects of exogenous testosterone and physical exercise on behavior in adult male rats. During two weeks, male Wistar rats underwent a gradual daily-increasing forced swimming exercise (trained, groups, tr) or not (non-trained groups, ntr) and were injected with testosterone (TSt groups) or solvent olive oil, control, Ctrl groups). The average swimming times until reaching the platform in the Morris water maze were significantly shorter in the TSt tr group as compared to other groups during the first day. Intergroup differences between the results from other behavioral tests did not reach the significance levels. Our results indicate that the combination of testosterone administration and physical exercise leads to improvement of spatial working memory. Further studies are needed to uncover the mechanism of this effect.

Keywords

androgens physical exercise water maze anxiety training 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    M. M. Cherrier, S. Asthana, S. Plymate, et al., “Testosterone supplementation improves spatial and verbal memory in healthy older men,” Neurology, 57, 80–88 (2001).PubMedCrossRefGoogle Scholar
  2. 2.
    A. Ulubaev, D. M. Lee, N. Purandare, et al., “Activational effects of sex hormones on cognition in men,” Clin. Endocrinol., 71, 607–623 (2009).CrossRefGoogle Scholar
  3. 3.
    J. van Honk, J. S. Peper, and D. Schutter, “Testosterone reduces unconscious fear but not consciously experienced anxiety: Implications for the disorders of fear and anxiety,” Biol. Psychiat., 58, 218–225 (2005).PubMedCrossRefGoogle Scholar
  4. 4.
    G. Fink, B. E. H. Sumner, J. K. McQueen, et al., “Sex steroid control of mood, mental state and memory,” Clin. Exp. Pharmacol. Physiol., 25, 764–775 (1998).PubMedCrossRefGoogle Scholar
  5. 5.
    J. Cendelin, I. Korelusova, and F. Vozeh, “The effect of cerebellar transplantation and enforced physical activity on motor skills and spatial learning in adult lurcher mutant mice,” Cerebellum, 8, 35–45 (2009).PubMedCrossRefGoogle Scholar
  6. 6.
    P. J. O’Connor, J. S. Raglin, and E. W. Martinsen, “Physical activity, anxiety and anxiety disorders,” Int. J. Sport Psychol., 31, 136–155 (2000).Google Scholar
  7. 7.
    D. S. Willoughby and L. Taylor, “Effects of sequential bouts of resistance exercise on androgen receptor expression,” Med. Sci. Sports Exerc., 36, 1499–1506 (2004).PubMedCrossRefGoogle Scholar
  8. 8.
    J. L. Vingren, W. J. Kraemer, D. L. Hatfield, et al., “Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women,” Steroids, 74, 1033–1039 (2009).PubMedCrossRefGoogle Scholar
  9. 9.
    R. G. M. Morris, “Spatial localization does not require the presence of local cues,” Learning Motivation, 12, 239–260 (1981).CrossRefGoogle Scholar
  10. 10.
    A. Ennaceur and K. Meliani, “A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory,” Behav. Brain Res., 51, 83–92 (1992).PubMedCrossRefGoogle Scholar
  11. 11.
    J. Crawley and F. K. Goodwin, “Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines,” Pharmacol. Biochem. Behav., 13, 167–170 (1980).PubMedCrossRefGoogle Scholar
  12. 12.
    C. A. Frye and A. A. Walf, “Depression-like behavior of aged male and female mice is ameliorated with administration of testosterone or its metabolites,” Physiol. Behav., 97, 266–269 (2009).PubMedCrossRefGoogle Scholar
  13. 13.
    T. E. Buddenberg, M. Komorowski, L. A. Ruocco, et al., “Attenuating effects of testosterone on depressive-like behavior in the forced swim test in healthy male rats,” Brain Res. Bull., 79, 182–186 (2009).PubMedCrossRefGoogle Scholar
  14. 14.
    M. Parle, M. Vasudevan, and N. Singh, “Swim everyday to keep dementia away,” J. Sport Sci. Med., 4, 37–46 (2005).Google Scholar
  15. 15.
    E. T. Ang, G. S. Dawe, P. T. H. Wong, et al., “Alterations in spatial learning and memory after forced exercise,” Brain Res., 1113, 186–193 (2006).PubMedCrossRefGoogle Scholar
  16. 16.
    T. Aubele, R. Kaufman, F. Montalmant, and M. F. Kritzer, “Effects of gonadectomy and hormone replacement on a spontaneous novel object recognition task in adult male rats,” Horm. Behav., 54, 244–252 (2008).PubMedCrossRefGoogle Scholar
  17. 17.
    C. A. Frye, K. Edinger, and K. Sumida, “Androgen administration to aged male mice increases antianxiety behavior and enhances cognitive performance,” Neuropsychopharmacology, 33, 1049–1061 (2008).PubMedCrossRefGoogle Scholar
  18. 18.
    K. L. Edinger and C. A. Frye, “Testosterone’s antianxiety and analgesic effects may be due in part to actions of its 5 alpha-reduced metabolites in the hippocampus,” Psychoneuroendocrinology, 30, 418–430 (2005).PubMedCrossRefGoogle Scholar
  19. 19.
    B. Fahey, S. Barlow, J. S. Day, and S. M. O’Mara, “Interferon-alpha-induced deficits in novel object recognition are rescued by chronic exercise,” Physiol. Behav., 95, 125–129 (2008).PubMedCrossRefGoogle Scholar
  20. 20.
    E. Binder, S. K. Droste, F. Ohl, and J. Reul, “Regular voluntary exercise reduces anxiety-related behaviour and impulsiveness in mice,” Behav. Brain Res., 155, 197–206 (2004).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • J. Hodosy
    • 1
    • 2
  • D. Ostatníková
    • 2
  • M Kúdela
    • 3
  • P. Celec
    • 1
    • 4
    • 5
    Email author
  1. 1.Institute of Molecular BiomedicineComenius UniversityBratislavaSlovakia
  2. 2.Institute of PhysiologyComenius UniversityBratislavaSlovakia
  3. 3.Department of ZoologyComenius UniversityBratislavaSlovakia
  4. 4.Institute of PathophysiologyComenius UniversityBratislavaSlovakia
  5. 5.Department of Molecular BiologyComenius UniversityBratislavaSlovakia

Personalised recommendations