, Volume 43, Issue 5, pp 369–376 | Cite as

Behavioral Activity and Anxiety of Rats under Open Field Conditions in the Norm and after Parenteral Introductions of Xenogenic Cerebrospinal Fluid

  • E. Yu. BessalovaEmail author

We studied the effects of injections of xenogenic cerebrospinal fluid (CSF) on behavioral phenomena in rats under open field conditions. Parenteral introduction of xenogenic liquor in adult male and female rats resulted in appreciable changes in the indices of spontaneous motor activity in the open field. Single and double CSF injections promoted intensification of motor and orientational/research activity followed by inhibition of the respective behavioral manifestations. Repeated CSF injections were accompanied by a gradual decrease in the behavioral activity of rats. In males and females, these changes were nearly synchronous. Injections of CSF also influenced the seasonal dynamics of behavioral phenomena in rats and cyclic changes in the activity of females during the estrous cycle. In the whole, CSF injections exerted more powerful effects than the action of main natural biological regulators (photoperiod and sex cycle). The presence of significant amounts of biologically active substances in the liquor, which are responsible for complex effects on links of the neuroendocrine regulatory system of recipients, is the probable basis of the revealed effects.


cerebrospinal fluid behavioral phenomena open field test sex-related differences seasonal (circannual) rhythms 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    V. S. Pikalyuk, E. Yu. Bessalova, V. V. Tkach, Jr., et al., Liquor as a Humoral Medium of the Organism [in Russian], IT “ARIAL,” Simferopol’ (2010).Google Scholar
  2. 2.
    A. P. Fridman, Fundamentals of Liquorology. Theory on the Brain Liquor [in Russian], Meditsina, Leningrad (1971).Google Scholar
  3. 3.
    E. Yu. Bessalova, Morphofunctional Modifications in the Ovaries of Mammals after Parenteral Introduction of Xenogenic Cerebrospinal Fluid [in Russian], Cand. Thesis, Med. Sci., Simferopol’ (2006).Google Scholar
  4. 4.
    J. Bureš, O. Burešova, and J. Hewstone, Technique and Basic Experiments for Studying the Brain and Behavior [Russian translation], A. S. Batuyev (ed.), Vysshaya Shkola, Moscow (1991).Google Scholar
  5. 5.
    S. Yu. Buslovich, A. I. Kotelenets, and R. M. Fridlyand, “Integral method for estimation of the behavior of albino rats in the open field,” Zh. Vyssh. Nerv. Deyat., 39, No. 1, 168–170 (1989).Google Scholar
  6. 6.
    H. F. Jackson and P. L. Broadhurst, “The effects of parachlorophenylalanine and stimulus intensity on openfield test measures in rats,” Neuropharmacology, 21, No. 12, 1279–1282 (1982).PubMedCrossRefGoogle Scholar
  7. 7.
    V. Kh. Khavinson and V. N. Anisimov, Peptide Bioregulators and Aging [in Russian], Nauka, Saint Petersburg (2003).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  1. 1.Georgievskii Crimean State Medical UniversitySimferopol’Ukraine

Personalised recommendations