Behavioral Modifications Related to Consumption of a “Soft” Adaptogen, Bee Honey, by Rats
Modifications of neurobehavioral activities related to single episodes of consumption of different doses of bee honey were examined in rats under conditions of the hole-board (HB) test (to evaluate the level of anxiety) and open-field (OF) test (where the intensities of locomotion, rearing, and grooming were measured). Animals of all subgroups had free access to normal saline, while rats of the three experimental subgroups consumed bee honey in the doses of 0.5, 1.0, and 2.0 g per 1 kg body mass (in the form of 10, 20, and 40% solutions, respectively). Among the doses tested, only higher ones induced considerable changes in the behavioral indices. The highest dose (2.0 g/kg) provided a more than twofold increase in the number of examined holes in the HB test; in the OF test, it also increased the numbers of crossed squares, rearings, and grooming episodes by 30, 37, and 164%, respectively. Thus, our experiments demonstrated a rather significant ability of the natural product tested to relieve anxiety and intensify motor, research/orientational, and grooming aspects of behavior even upon single acts of consumption. Possible neurophysiological mechanisms underlying the behavioral modifications observed are discussed.
Keywordsbehavioral activities hole-board test open-field test anxiety bee honey
Unable to display preview. Download preview PDF.
- 1.National Honey Board, Carbohydrate and the Sweetness of Honey (last accessed May 5, 2008 at http//www.honey.com).
- 2.Oregon State University Sugar Sweetness (last accessed May 5, 2008 at http//www.food.oregonstate.edu/sugar).
- 3.USDA Nutrient Data Laboratory Honey (last accessed August 24, 2007 at http//www.nal.usda.gov/fnic/food).
- 4.J. R. Boissier and P. Simon. “L’utilization du test de la traction (Test de JULOU-COURVOISIER) pour l’etude des psycholeptiques,” Therapie, 15, 1170–1174 (1960).Google Scholar
- 6.P. C. Molan, “Honey for treatment of infections,” The New Zealand Bee Keeper, 216, 19–20 (1992).Google Scholar
- 10.I. Lucki, “Serotonin receptor specificity in anxiety disorders,” J. Clin. Psychiat. 57, Suppl. 6, 5–10 (1996).Google Scholar