EGFR gene amplification in monocentric and multicentric glioblastoma
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To the Editor,
Glioblastomas (GBMs) are called multicentric when multiple independent foci develop in a single patient. In the majority of the cases, these multicentric foci arise from a single monoclonal tumors and therefore reflect merely an increased propensity to disseminate [1, 2]. Amplification of the epidermal growth factor receptor (EGFR) gene affect 40% of GBM and EGF pathway activation promotes glioma invasiveness [3, 4]. We thus aimed to investigate the association between EGFR amplification and multicentricity.
Patients (≥ 18 years) were identified from our database (OncoNeuroTek, GH Pitié-Salpêtrière) according to the following criteria: (1) histological diagnosis of GBM IDH wild type (2) available tumor sample and (3) written informed consent.
L. Nichelli study concept and design, acquisition and interpretation of data, drafting manuscript. L. Nichelli and D. Dormont imaging data collection and interpretation. A. L. Di Stefano, M. Sanson study concept and design, acquisition and interpretation of data, drafting manuscript, responsibility for the integrity of the study. All read and approved the manuscript.
Compliance with ethical standards
Conflict of interest
Authors declare no conflict of interest.
- 1.Abou-El-Ardat K et al (2017) Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas. Neurooncology 19:546–557Google Scholar