Journal of Neuro-Oncology

, Volume 145, Issue 3, pp 587–589 | Cite as

EGFR gene amplification in monocentric and multicentric glioblastoma

  • Lucia Nichelli
  • Didier Dormont
  • Marc Sanson
  • Anna Luisa Di StefanoEmail author
Letter to the Editor

To the Editor,

Glioblastomas (GBMs) are called multicentric when multiple independent foci develop in a single patient. In the majority of the cases, these multicentric foci arise from a single monoclonal tumors and therefore reflect merely an increased propensity to disseminate [1, 2]. Amplification of the epidermal growth factor receptor (EGFR) gene affect 40% of GBM and EGF pathway activation promotes glioma invasiveness [3, 4]. We thus aimed to investigate the association between EGFR amplification and multicentricity.

Patients (≥ 18 years) were identified from our database (OncoNeuroTek, GH Pitié-Salpêtrière) according to the following criteria: (1) histological diagnosis of GBM IDH wild type (2) available tumor sample and (3) written informed consent.

By simultaneously evaluating both fluid-attenuated inversion recovery (FLAIR) and T1 post-contrast magnetic resonance imaging (MRI) sequences we classified tumor as multicentric when no evidence of anatomical continuity (no FLAIR...


Author contributions

L. Nichelli study concept and design, acquisition and interpretation of data, drafting manuscript. L. Nichelli and D. Dormont imaging data collection and interpretation. A. L. Di Stefano, M. Sanson study concept and design, acquisition and interpretation of data, drafting manuscript, responsibility for the integrity of the study. All read and approved the manuscript.

Compliance with ethical standards

Conflict of interest

Authors declare no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.AP-HP, Neuroradiology DepartmentHôpitaux Universitaires Pitié Salpêtrière - Charles FoixParisFrance
  2. 2.University of Modena and Reggio Emilia Department of Diagnostic ImagingModenaItaly
  3. 3.Inserm U 1127, CNRS UMR 7225, Sorbonne Université, UPMC Univ Paris 06 UMR S 1127Institut du Cerveau et de la Moelle épinière, ICMParisFrance
  4. 4.AP-HP, Hôpital de La Pitié-Salpêtrière, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie Mazarin 2ParisFrance
  5. 5.OncoNeuroTek, Institut du Cerveau et de la Moelle épinièreParisFrance
  6. 6.Department of NeurologyFoch HospitalParisFrance

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