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Journal of Neuro-Oncology

, Volume 145, Issue 3, pp 587–589 | Cite as

EGFR gene amplification in monocentric and multicentric glioblastoma

  • Lucia Nichelli
  • Didier Dormont
  • Marc Sanson
  • Anna Luisa Di StefanoEmail author
Letter to the Editor
  • 51 Downloads

To the Editor,

Glioblastomas (GBMs) are called multicentric when multiple independent foci develop in a single patient. In the majority of the cases, these multicentric foci arise from a single monoclonal tumors and therefore reflect merely an increased propensity to disseminate [1, 2]. Amplification of the epidermal growth factor receptor (EGFR) gene affect 40% of GBM and EGF pathway activation promotes glioma invasiveness [3, 4]. We thus aimed to investigate the association between EGFR amplification and multicentricity.

Patients (≥ 18 years) were identified from our database (OncoNeuroTek, GH Pitié-Salpêtrière) according to the following criteria: (1) histological diagnosis of GBM IDH wild type (2) available tumor sample and (3) written informed consent.

By simultaneously evaluating both fluid-attenuated inversion recovery (FLAIR) and T1 post-contrast magnetic resonance imaging (MRI) sequences we classified tumor as multicentric when no evidence of anatomical continuity (no FLAIR...

Notes

Author contributions

L. Nichelli study concept and design, acquisition and interpretation of data, drafting manuscript. L. Nichelli and D. Dormont imaging data collection and interpretation. A. L. Di Stefano, M. Sanson study concept and design, acquisition and interpretation of data, drafting manuscript, responsibility for the integrity of the study. All read and approved the manuscript.

Compliance with ethical standards

Conflict of interest

Authors declare no conflict of interest.

References

  1. 1.
    Abou-El-Ardat K et al (2017) Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas. Neurooncology 19:546–557Google Scholar
  2. 2.
    Akimoto J et al (2014) A case of radiologically multicentric but genetically identical multiple glioblastomas. Brain Tumor Pathol 31:113–117CrossRefGoogle Scholar
  3. 3.
    Lund-Johansen M et al (1990) Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro. Cancer Res 50:6039–6044PubMedGoogle Scholar
  4. 4.
    Talasila KM et al (2013) EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathol (Berl) 125:683–698CrossRefGoogle Scholar
  5. 5.
    Idbaih A et al (2007) Tumor genomic profiling and TP53 germline mutation analysis of first-degree relative familial gliomas. Cancer Genet Cytogenet 176:121–126CrossRefGoogle Scholar
  6. 6.
    Lasocki A, Gaillard F, Tacey MA, Drummond KJ, Stuckey SL (2016) The incidence and significance of multicentric noncontrast-enhancing lesions distant from a histologically-proven glioblastoma. J Neurooncol 129:471–478CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.AP-HP, Neuroradiology DepartmentHôpitaux Universitaires Pitié Salpêtrière - Charles FoixParisFrance
  2. 2.University of Modena and Reggio Emilia Department of Diagnostic ImagingModenaItaly
  3. 3.Inserm U 1127, CNRS UMR 7225, Sorbonne Université, UPMC Univ Paris 06 UMR S 1127Institut du Cerveau et de la Moelle épinière, ICMParisFrance
  4. 4.AP-HP, Hôpital de La Pitié-Salpêtrière, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie Mazarin 2ParisFrance
  5. 5.OncoNeuroTek, Institut du Cerveau et de la Moelle épinièreParisFrance
  6. 6.Department of NeurologyFoch HospitalParisFrance

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