Journal of Neuro-Oncology

, Volume 145, Issue 3, pp 487–499 | Cite as

Complementary and alternative medicine use in glioma patients in France

  • Emilie Le RhunEmail author
  • Patrick Devos
  • Véronique Bourg
  • Amélie Darlix
  • Véronique Lorgis
  • Guido Ahle
  • Mathieu Boone
  • Luc Taillandier
  • Elsa Curtit
  • Louis Gras
  • Christine Lebrun Frenay
  • Dorothee Gramatzki
  • Carole Ramirez
  • Nicolas Simon
  • Michael Weller
Clinical Study



Complementary and alternative medicine (CAM) use increases in cancer patients, including adult patients with diffuse gliomas.


Questionnaires addressing CAM use were distributed to adult patients with gliomas of WHO grades II-IV and ECOG performance score of 0–2 during hospital visits and filled in anonymously. The study was conducted in nine centers in France from May 2017 to May 2018. Descriptive cohort analyses and comparative analyses according to gender, age, WHO grade, and recurrent versus newly diagnosed disease were conducted.


Two hundred twenty-seven questionnaires were collected; 135 patients (59%) were male. Median age was 48 years, 105 patients (46%) declared having glioblastoma, 99 patients (43%) declared having recurrent disease. Hundred-three patients (45%) had modified their alimentary habits after the glioma diagnosis. At the time of the questionnaire, 100 patients (44%) were on complementary treatment, mainly vitamins and food supplements, and 73 patients (32%) used alternative medicine approaches, mainly magnetism and acupuncture. In total, 154 patients (68%) declared using at least one of these approaches. Expenditures exceeding 100 € per month were reported by users in 14% for modification of alimentary habits, in 25% for complementary treatment, and in 18% for alternative medicines. All approaches were commonly considered as improving quality of life and experienced as efficient, notably those associated with more expenditures.


CAM are frequently used by glioma patients in France. Underlying needs and expectations, as well as potential interactions with tumor-specific treatments, and financial and quality of life burden, should be discussed with patients and caregivers.


Acupuncture Brain Diet Magnetism Supplements Vitamins 



The authors would like to thank Stéphanie Heudre for excellent administrational support.

Supplementary material

11060_2019_3315_MOESM1_ESM.docx (201 kb)
Electronic supplementary material 1 (DOCX 202 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Emilie Le Rhun
    • 1
    • 2
    • 3
    • 14
    Email author
  • Patrick Devos
    • 4
  • Véronique Bourg
    • 5
  • Amélie Darlix
    • 6
  • Véronique Lorgis
    • 7
  • Guido Ahle
    • 8
  • Mathieu Boone
    • 9
  • Luc Taillandier
    • 10
  • Elsa Curtit
    • 11
  • Louis Gras
    • 12
  • Christine Lebrun Frenay
    • 5
  • Dorothee Gramatzki
    • 3
  • Carole Ramirez
    • 2
  • Nicolas Simon
    • 13
  • Michael Weller
    • 3
  1. 1.Univ. Lille, U1192 - PRISMLilleFrance
  2. 2.CHU Lille, Neuro-oncology, General and Stereotaxic Neurosurgery DepartmentLilleFrance
  3. 3.Department of NeurologyUniversity Hospital and University of Zurich, Frauenklinikstrasse 26ZurichSwitzerland
  4. 4.Univ. Lille, CHU Lille, EA 2694 - Santé Publique: Épidémiologie et Qualité des SoinsLilleFrance
  5. 5.Department of Neurology, Pasteur2 HospitalNice Côte D’Azur UniversityNiceFrance
  6. 6.Department of Medical Oncology, Institut du Cancer de MontpellierUniversity of MontpellierMontpellierFrance
  7. 7.Georges François LeclercDijonFrance
  8. 8.Department of Neurology, Hôpitaux CivilsColmarFrance
  9. 9.Department of Medical Oncology, CHUAmiensFrance
  10. 10.University HospitalNancyFrance
  11. 11.University HospitalBesançonFrance
  12. 12.Centre Léonard de VinciDechyFrance
  13. 13.Univ. Lille, CHU Lille, EA 7365 – GRITA – Groupe de Recherche sur les Formes Injectables et les Technologies AssociéesLilleFrance
  14. 14.Neuro-Oncology, Neurosurgery Department, Roger Salengro Hospital, Rue Emile LaineUniversity Hospital CHRULille CedexFrance

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