Journal of Neuro-Oncology

, Volume 145, Issue 1, pp 143–150 | Cite as

Surgery for temporal glioblastoma: lobectomy outranks oncosurgical-based gross-total resection

  • Matthias SchneiderEmail author
  • Anna-Laura Potthoff
  • Vera C. Keil
  • Ági Güresir
  • Johannes Weller
  • Valeri Borger
  • Motaz Hamed
  • Andreas Waha
  • Hartmut Vatter
  • Erdem Güresir
  • Ulrich Herrlinger
  • Patrick Schuss
Clinical Study



Supra-total glioblastoma resection has gained growing attention with regard to superior long-term disease control. However, aggressive onco-surgical approaches—geared beyond conventional gross total resections (GTR)—are limited by the impairment of adjacent eloquent areas at risk that may entail severe postoperative functional morbidity. Against this backdrop we analyzed our institutional database with regard to potential survival benefits of anterior temporal lobectomy as a paradigm for supra-total resection in patients with precisely temporal-located, non-eloquent glioblastoma.


Between 2012 and 2017, 38 patients with isolated temporal glioblastoma underwent GTR or temporal lobectomy at the authors’ institution. Both groups of differing resection modalities were compared with regard to postoperative Karnofsky performance score (KPS), progression-free survival (PFS), and overall survival (OS).


Patients with temporal lobectomy exhibited significantly superior median KPS at the 12 months follow-up compared to the GTR group (median KPS of 80 vs. 60, p = 0.04). Temporal lobectomy was associated with significantly prolonged PFS (p = 0.005) and OS (p = 0.002) coming up to 15 months (95% CI 9.7–22.1) and 23 months (95% CI 14.8–34.5) compared to 7 months (95% CI 3.3–8.3) and 11 months (95% CI 9.2–17.9) for the GTR group. Multivariate analysis revealed temporal lobectomy as the only predictor for both superior PFS (p = 0.037, OR 7.3, 95% CI 1.1–47.4) and OS (p = 0.04, OR 7.8, 95% CI 1.1–55.2).


These results strongly suggest temporal lobectomy as an aggressive supra-total resection policy to constitute the surgical modality of choice for isolated temporal-located glioblastoma.


Glioblastoma Lobectomy Gross-total resection Overall survival 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest

Ethical approval

The present study was approved by the local ethics committee af the University of Bonn.

Informed consent

Informed consent was not sought as a retrospective design was used.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Matthias Schneider
    • 1
    Email author
  • Anna-Laura Potthoff
    • 1
  • Vera C. Keil
    • 2
  • Ági Güresir
    • 1
  • Johannes Weller
    • 3
  • Valeri Borger
    • 1
  • Motaz Hamed
    • 1
  • Andreas Waha
    • 4
  • Hartmut Vatter
    • 1
  • Erdem Güresir
    • 1
  • Ulrich Herrlinger
    • 3
  • Patrick Schuss
    • 1
  1. 1.Department of NeurosurgeryRheinische Friedrich-Wilhelms-UniversityBonnGermany
  2. 2.Department of RadiologyRheinische Friedrich-Wilhelms-UniversityBonnGermany
  3. 3.Division of Clinical Neurooncology, Department of NeurologyRheinische Friedrich-Wilhelms-UniversityBonnGermany
  4. 4.Department of NeuropathologyRheinische Friedrich-Wilhelms-UniversityBonnGermany

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