Journal of Neuro-Oncology

, Volume 143, Issue 1, pp 175–176 | Cite as

Comment on: Effects of surgery on neurocognitive function in patients with glioma: a meta-analysis of immediate post-operative and long-term follow-up neurocognitive outcomes

  • Sophie J. M. RijnenEmail author
  • Margriet M. Sitskoorn
  • Karin Gehring
Letter to the Editor

To the Editor,

With great interest we have read the meta-analysis by Ng et al. [1] on ‘Effects of surgery on neurocognitive function in patients with glioma’ which was recently published in this journal. The authors aimed to identify the tests that are commonly used for neuropsychological assessment in glioma patients. Furthermore, they aimed to quantify changes in cognitive function in glioma patients on the short and long term after surgery. Based on 11 studies that were included in the meta-analysis, it was concluded that surgery in glioma patients confers a benefit for performance on all cognitive domains that were assessed, except for executive functions which deteriorated after surgery. In addition, the authors underscore the need for more prospective and longitudinal studies assessing the effects of surgery on cognitive functioning in patients with glioma, and recommend using a standardized neuropsychological assessment battery in doing so.

Although this meta-analysis draws...



Funding was funded by ZonMw (Grant no: 842003007).


  1. 1.
    Ng JCH, See AAQ, Ang TY, Tan LYR, Ang BT, King NKK (2018) Effects of surgery on neurocognitive function in patients with glioma: a meta-analysis of immediate post- operative and long-term follow-up neurocognitive outcomes. J Neurooncol. CrossRefPubMedGoogle Scholar
  2. 2.
    Van Loenen IS, Rijnen SJM, Bruijn J, Rutten GJM, Gehring K, Sitskoorn MM (2018) Group changes in cognitive performance after surgery mask changes in individual patients with Glioblastoma. World Neurosurg 117:e172–e179. CrossRefPubMedGoogle Scholar
  3. 3.
    Lee CH, Cook S, Lee JS, Han B (2016) Comparison of two meta-analysis methods: inverse- variance-weighted-average and weighted sum of z-scores. Genomics Inform 14(3):173–180. CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Elisabeth-TweeSteden HospitalTilburgThe Netherlands
  2. 2.Tilburg UniversityTilburgThe Netherlands
  3. 3.Tilburg UniversityTilburgThe Netherlands

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