Advertisement

Journal of Neuro-Oncology

, Volume 140, Issue 3, pp 687–696 | Cite as

Social cognition in patients with intracranial tumors: do we forget something in the routine neuropsychological examination?

  • Simone Goebel
  • H. Maximilian Mehdorn
  • Christian D. Wiesner
Clinical Study

Abstract

Purpose

Social cognitive functions are of high clinical relevance. To date, little is known about social cognition in neurooncological patients and this domain is usually not included in standardized neurocognitive test batteries. Aim of this study was thus to assess whether social cognition could pose a useful contribution to the neurocognitive assessment in patients with intracranial tumors.

Methods

We included 30 preoperative patients with a brain tumor. Patients completed a comprehensive test battery for assessment of social cognition. Thirty healthy participants matched for age, gender, and education, served as control group. Clinical relevance of social cognitive deficits was assessed via various self-report measures as well as a clinical rating scale assessing social and occupational functioning.

Results

Twenty-five patients (83%) were impaired in at least one measure of social cognition. Whereas patients with lesions to the temporal lobes were most severely impaired, deficits occurred in patients with tumors of a variety of localizations, sizes and malignancies. There was some evidence for missing patients’ awareness as well as clinical significance of social cognitive deficits in terms of impaired interactional and occupational functioning. By combination of the Faux-Pas and the Eyes-Test, 77% of patients who were impaired in any social cognitive task were detected.

Conclusions

Deficits in social cognition are frequent and clinically relevant in patients with intracranial tumors. The inclusion of social cognitive measures in the routine neuropsychological examination for brain tumor patients might add valuable information about the patient whilst requiring reasonable additional resources.

Keywords

Brain tumor Social cognition Theory of Mind Empathy Psychological assessment Neuropsychology 

Notes

Compliance with ethical standards

Conflict of interest

None.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the Ethical Standards of the Institutional and/or National Research Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Tucha O, Smely C, Preier M et al (2000) Cognitive deficits before treatment among patients with brain tumors. Neurosurgery 47:324–334.  https://doi.org/10.1097/00006123-200008000-00011 CrossRefGoogle Scholar
  2. 2.
    Shen C, Bao W-M, Yang B-J et al (2012) Cognitive deficits in patients with brain tumor. Chin Med J 125:2610–2617Google Scholar
  3. 3.
    Armstrong CL, Goldstein B, Shera D et al (2003) The predictive value of longitudinal neuropsychologic assessment in the early detection of brain tumor recurrence. Cancer 97:649–656.  https://doi.org/10.1002/cncr.11099 CrossRefGoogle Scholar
  4. 4.
    Taphoorn MJB, Klein M (2004) Cognitive deficits in adult patients with brain tumours. Lancet Neurol 3:159–168.  https://doi.org/10.1016/S1474-4422(04)00680-5 CrossRefGoogle Scholar
  5. 5.
    Heimans JJ, Taphoorn MJB (2002) Impact of brain tumour treatment on quality of life. J Neurol 249:955–960.  https://doi.org/10.1007/s00415-002-0839-5 CrossRefGoogle Scholar
  6. 6.
    Kelly M, McDonald S, Frith MHJ (2017) A survey of clinicians working in brain injury rehabilitation: are social cognition impairments on the radar? J Head Trauma Rehabil 32:E55–E65.  https://doi.org/10.1097/HTR.0000000000000269 CrossRefGoogle Scholar
  7. 7.
    Kelly M, McDonald S, Frith MHJ (2017) Assessment and rehabilitation of social cognition impairment after brain injury: surveying practices of clinicians. Brain Impair 18:11–35.  https://doi.org/10.1017/BrImp.2016.34 CrossRefGoogle Scholar
  8. 8.
    Turchi F, Cuomo A, Amodeo G et al (2017) The neural bases of social cognition in major depressive disorder: a review. Riv Psichiatr 52:137–149.  https://doi.org/10.1708/2737.27906 Google Scholar
  9. 9.
    Premack D, Woodruff G (1978) Does the chimpanzee have a theory of mind? Behav Brain Sci 1:515.  https://doi.org/10.1017/S0140525X00076512 CrossRefGoogle Scholar
  10. 10.
    Baglio F, Marchetti A (2016) Editorial: when (and how) is theory of mind useful? Evidence from life-span research. Front Psychol 7:1425.  https://doi.org/10.3389/fpsyg.2016.01425 Google Scholar
  11. 11.
    Kar N, Kar B (2017) Social cognition and individual effectiveness in interpersonal scenarios: a conceptual review. J Ment Health Hum Behav 22:27.  https://doi.org/10.4103/0971-8990.210705 CrossRefGoogle Scholar
  12. 12.
    Brioschi Guevara A, Knutson KM, Wassermann EM et al (2015) Theory of mind impairment in patients with behavioural variant fronto-temporal dementia (bv-FTD) increases caregiver burden. Age Ageing 44:891–895.  https://doi.org/10.1093/ageing/afv059 CrossRefGoogle Scholar
  13. 13.
    Martín-Rodríguez JF, León-Carrión J (2010) Theory of mind deficits in patients with acquired brain injury: a quantitative review. Neuropsychologia 48:1181–1191.  https://doi.org/10.1016/j.neuropsychologia.2010.02.009 CrossRefGoogle Scholar
  14. 14.
    Shamay-Tsoory SG, Aharon-Peretz J (2007) Dissociable prefrontal networks for cognitive and affective theory of mind: a lesion study. Neuropsychologia 45:3054–3067.  https://doi.org/10.1016/j.neuropsychologia.2007.05.021 CrossRefGoogle Scholar
  15. 15.
    Mattavelli G, Pisoni A, Casarotti A et al (2017) Consequences of brain tumour resection on emotion recognition. J Neuropsychol.  https://doi.org/10.1111/jnp.12130 Google Scholar
  16. 16.
    Campanella F, Shallice T, Ius T et al (2014) Impact of brain tumour location on emotion and personality: a voxel-based lesion-symptom mapping study on mentalization processes. Brain 137:2532–2545.  https://doi.org/10.1093/brain/awu183 CrossRefGoogle Scholar
  17. 17.
    Lezak MD, Howieson DB, Bigler ED, Tranel D (2012) Neuropsychological assessment, 5th edn. University Press, OxfordGoogle Scholar
  18. 18.
    Hubert W, Poeck K, Willmes-von-Hinckeldey K et al (1983) Aachener Aphasie TestGoogle Scholar
  19. 19.
    Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198CrossRefGoogle Scholar
  20. 20.
    Berth H, Petrowski K, Balck F (2007) The Amsterdam Preoperative Anxiety and Information Scale (APAIS)—the first trial of a German version. Psychosoc Med. http://www.egms.de/en/journals/psm/2007-4/psm000033.shtml
  21. 21.
    Warrington EKJM (1992) Testbatterie für visuelle Objekt- und Raumwahrnehmung (VOSP)Google Scholar
  22. 22.
    Schenkenberg T, Bradford DC, Ajax ET (1980) Line bisection and unilateral visual neglect in patients with neurologic impairment. Neurology 30:509.  https://doi.org/10.1212/WNL.30.5.509 CrossRefGoogle Scholar
  23. 23.
    Härting C, Markowitsch HJ, Neufeld H, Calabrese P, Deisinger K, Kessler J (2000) Wechsler Gedächtnistest—Revidierte Fassung(WMS-R)Google Scholar
  24. 24.
    Regard M, Strauss E, Knapp P (1982) Children’s production on verbal and non-verbal fluency tasks. Percept Mot Skills 55:839–844.  https://doi.org/10.2466/pms.1982.55.3.839 CrossRefGoogle Scholar
  25. 25.
    Goebel S, Mehdorn HM (2013) Development of anxiety and depression in patients with benign intracranial meningiomas: a prospective long-term study. Support Care Cancer 21:1365–1372.  https://doi.org/10.1007/s00520-012-1675-5 CrossRefGoogle Scholar
  26. 26.
    Lundqvist D, Flykt A, Öhman A (1998) The Karolinska directed emotional faces (KDEF) (database of standardized facial images)Google Scholar
  27. 27.
    Washburn AM, Sands LP, Walton PJ (2003) Assessment of social cognition in frail older adults and its association with social functioning in the nursing home. Gerontologist 43:203–212.  https://doi.org/10.1093/geront/43.2.203 CrossRefGoogle Scholar
  28. 28.
    Roudier M, Marcie P, Grancher A-S et al (1998) Discrimination of facial identity and of emotions in Alzheimer’s disease. J Neurol Sci 154:151–158.  https://doi.org/10.1016/S0022-510X(97)00222-0 CrossRefGoogle Scholar
  29. 29.
    Bölte S, Poustka F, Constantino JN, Gruber CP (2005) SRS: Skala zur Erfassung sozialer Reaktivität: dimensionale Autismus-DiagnostikGoogle Scholar
  30. 30.
    Baron-Cohen S, Wheelwright S, Hill J et al (2001) The “Reading the Mind in the Eyes” test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 42:241–251.  https://doi.org/10.1017/S0021963001006643 CrossRefGoogle Scholar
  31. 31.
    Schacher M, Winkler R, Grunwald T et al (2006) Mesial temporal lobe epilepsy impairs advanced social cognition. Epilepsia 47:2141–2146.  https://doi.org/10.1111/j.1528-1167.2006.00857.x CrossRefGoogle Scholar
  32. 32.
    Baron-Cohen S, O’Riordan M, Stone V et al (1999) Recognition of Faux Pas by normally developing children and children with Asperger syndrome or high-functioning autism. J Autism Dev Disord 29:407–418.  https://doi.org/10.1023/A:1023035012436 CrossRefGoogle Scholar
  33. 33.
    Völlm BA, Taylor ANW, Richardson P et al (2006) Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task. Neuroimage 29:90–98.  https://doi.org/10.1016/j.neuroimage.2005.07.022 CrossRefGoogle Scholar
  34. 34.
    Sarfati Y, Hardybayle M, Besche C et al (1997) Attribution of intentions to others in people with schizophrenia: a non-verbal exploration with comic strips. Schizophr Res 25:199–209.  https://doi.org/10.1016/S0920-9964(97)00025-X CrossRefGoogle Scholar
  35. 35.
    Brunet E, Sarfati Y, Hardy-Baylé MC et al (2000) A PET investigation of the attribution of intentions with a nonverbal task. Neuroimage 11:157–166.  https://doi.org/10.1006/nimg.1999.0525 CrossRefGoogle Scholar
  36. 36.
    Baron-Cohen S, Wheelwright S (2004) The Empathy Quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. J Autism Dev Disord 34:163–175.  https://doi.org/10.1023/B:JADD.0000022607.19833.00 CrossRefGoogle Scholar
  37. 37.
    Haen Jd (2007) Empathy quotient (EQ): Deutsche Version des Empathy Quotient (EQ) von Baron-Cohen. https://www.autismresearchcentre.com/arc_tests. Accessed 9 April 2018
  38. 38.
    Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–370.  https://doi.org/10.1111/j.1600-0447.1983.tb09716.x CrossRefGoogle Scholar
  39. 39.
    Gauggel S (1999) Die Marburger Kompetenz-Skala: Unveröffentliches ManuskriptGoogle Scholar
  40. 40.
    von Wietersheim J, Ennulat A, Probst B, Wilke E et al (1989) Construction and preliminary assessments of a questionnaire on social integration. Diagnostica 35:359–363Google Scholar
  41. 41.
    Weissman MM (1976) Assessment of social adjustment by patient self-report. Arch Gen Psychiatry 33:1111.  https://doi.org/10.1001/archpsyc.1976.01770090101010 CrossRefGoogle Scholar
  42. 42.
    Sass H, Wittchen HU, Zaudig M (1996) Skala zur Erfassung des sozialen und beruflichen Funktionsniveaus (SOFAS): Diagnostisches und Statistisches Manual psychischer Störungen. In: American Psychiatric Association (ed) DSM-IV: Übersetzt nach der vierten Auflage des Diagnostic and Statistical Manual of Mental Disorders. Hogrefe, GöttingenGoogle Scholar
  43. 43.
    Lenhard W, Lenhard A (2014) Testing the significance of correlations. UnpublishedGoogle Scholar
  44. 44.
    Kelleher M, Tolea MI, Galvin JE (2016) Anosognosia increases caregiver burden in mild cognitive impairment. Int J Geriatr Psychiatry 31:799–808.  https://doi.org/10.1002/gps.4394 CrossRefGoogle Scholar
  45. 45.
    Frith U (1994) Autism and theory of mind in everyday life. Soc Dev 3:108–124.  https://doi.org/10.1111/j.1467-9507.1994.tb00031.x CrossRefGoogle Scholar
  46. 46.
    McDonald S (2017) What’s new in the clinical management of disorders of social cognition? Brain Impair 18:2–10.  https://doi.org/10.1017/BrImp.2017.2 CrossRefGoogle Scholar
  47. 47.
    Roelofs RL, Wingbermühle E, Egger JIM, Kessels RPC (2017) Social cognitive interventions in neuropsychiatric patients: a meta-analysis. Brain Impair 18:138–173CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Clinical Psychology and Psychotherapy, Institute of PsychologyChristian-Albrechts-UniversityKielGermany
  2. 2.Mehdorn ConsiliumKielGermany

Personalised recommendations