Journal of Neuro-Oncology

, Volume 140, Issue 3, pp 639–647 | Cite as

Clinical and prognostic features of spinal meningioma: a thorough analysis from a single neurosurgical center

  • Lingyang Hua
  • Hongda Zhu
  • Jiaojiao Deng
  • Mi Tian
  • Xuewei Jiang
  • Hailiang Tang
  • Shihai Luan
  • Hiroaki Wakimoto
  • Qing XieEmail author
  • Ye GongEmail author
Clinical Study



The aim of this study was to thoroughly analyze the clinical characteristics of a large cohort of spinal meningioma (SM) from a single neurological center and identify risk factors associated with worse progression free survival and neurological function outcome.


Clinical information was retrieved from 483 SM and 9806 cranial meningioma cases who were operated in our center between 2003 and 2013. 194 SM patients who were followed at the main branch were used for prognostic analyses that included both recurrence free survival and neurological functions based on Modified McCormick scale (MMS).


Females were predominant (P < 0.001). High grade tumors were not common (WHO grade II, 2.9%; grade III, 1.7%), while the clear cell subtype was frequent within grade II SMs (6/14, 42.9%). Macroscopic total resection was achieved in all SMs (Simpson grade I, 30.9%; grade II, 65.5%; grade III, 3.6%) with a low complications rate (4.6%) and provided neurological improvement in 80 patients (41.2%). Recurrence was seen in 9 cases (4.6%) and associated with high WHO grade, male, prior recurrence, and Simpson grade III. High WHO grade and high Ki-67 index were identified to be independent factors predictive of both neurological function deterioration and impaired post-operative neurological status.


Our analysis of the largest SM cohort in scale from a single institution offers a comprehensive view of the clinical characteristics of surgically treated SM, revealing the distinct biology of SM in comparison to its cranial counterparts, and providing guidance to improve surgical management of SM.


Spinal meningioma Epidemiology Neurological function Prognosis Recurrence 



Spinal meningioma


Modified McCormick scale


T1 Weighted image


Magnetic resonance imaging


Progesterone receptor


Progression free survival


Somatosensory evoked potentials


Motor evoked potentials



The work has not been submitted elsewhere for publication, in whole or in part. This study was supported by grants from the National Natural Science Foundation of China (81772674 to Y. Gong) and the Science and Technology Commission of Shanghai Municipality (18140900200 and 16140903000 to Y. Gong).

Compliance with ethical standards


The authors had no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

Supplementary material

11060_2018_2993_MOESM1_ESM.tif (99.3 mb)
Supplementary Fig 1. Sagittal location of SM in the initial cohort. (TIF 101632 KB)
11060_2018_2993_MOESM2_ESM.tif (34.7 mb)
Supplementary Fig 2. Pathological distribution of SM based on gender in the initial cohort. (TIF 35582 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Neurosurgery, Huashan Hospital, Shanghai Medical CollegeFudan UniversityShanghaiChina
  2. 2.Department of Critical Medicine, Huashan Hospital, Shanghai Medical CollegeFudan UniversityShanghaiChina
  3. 3.Department of Neurosurgery, Massachusetts General HospitalHarvard Medical SchoolBostonUSA

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