Clinical and prognostic features of spinal meningioma: a thorough analysis from a single neurosurgical center
The aim of this study was to thoroughly analyze the clinical characteristics of a large cohort of spinal meningioma (SM) from a single neurological center and identify risk factors associated with worse progression free survival and neurological function outcome.
Clinical information was retrieved from 483 SM and 9806 cranial meningioma cases who were operated in our center between 2003 and 2013. 194 SM patients who were followed at the main branch were used for prognostic analyses that included both recurrence free survival and neurological functions based on Modified McCormick scale (MMS).
Females were predominant (P < 0.001). High grade tumors were not common (WHO grade II, 2.9%; grade III, 1.7%), while the clear cell subtype was frequent within grade II SMs (6/14, 42.9%). Macroscopic total resection was achieved in all SMs (Simpson grade I, 30.9%; grade II, 65.5%; grade III, 3.6%) with a low complications rate (4.6%) and provided neurological improvement in 80 patients (41.2%). Recurrence was seen in 9 cases (4.6%) and associated with high WHO grade, male, prior recurrence, and Simpson grade III. High WHO grade and high Ki-67 index were identified to be independent factors predictive of both neurological function deterioration and impaired post-operative neurological status.
Our analysis of the largest SM cohort in scale from a single institution offers a comprehensive view of the clinical characteristics of surgically treated SM, revealing the distinct biology of SM in comparison to its cranial counterparts, and providing guidance to improve surgical management of SM.
KeywordsSpinal meningioma Epidemiology Neurological function Prognosis Recurrence
Modified McCormick scale
T1 Weighted image
Magnetic resonance imaging
Progression free survival
Somatosensory evoked potentials
Motor evoked potentials
The work has not been submitted elsewhere for publication, in whole or in part. This study was supported by grants from the National Natural Science Foundation of China (81772674 to Y. Gong) and the Science and Technology Commission of Shanghai Municipality (18140900200 and 16140903000 to Y. Gong).
Compliance with ethical standards
The authors had no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.
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