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Journal of Neuro-Oncology

, Volume 140, Issue 2, pp 367–375 | Cite as

Interaction of quality of life, mood and depression of patients and their informal caregivers after surgical treatment of high-grade glioma: a prospective study

  • Maxi Sacher
  • Jürgen Meixensberger
  • Wolfgang Krupp
Clinical Study

Abstract

Introduction

Patients who are diagnosed with high-grade gliomas (HGG) have poor prognoses and often experience rapid declines in functional and cognitive status, which makes caring for them particularly stressful. We conducted a prospective study to investigate the factors influencing the quality of life of HGG patients and their informal caregivers and analyzed their reciprocal impacts. Based on our results, we elaborated a screening model to identify patients and caregivers in need of psychooncological support.

Methods

A total of 45 matched HGG patient–caregiver dyads completed the Multidimensional Mood State Questionnaire, the 12-Item Short Form Medical Outcome Questionnaire and the Center for Epidemiology Studies Depression Scale. A subsequent semi-structured interview was performed with each individual.

Results

We found a significant relationship between the mood and depression scores of patients and caregivers, with a third of them displaying symptoms of a major depressive episode. Our screening model showed that 73% of the dyads exhibited signs of severe emotional strain with the need of psychooncological support. Beneficial factors that helped patients and caregivers cope with the illness included mutual respect, good communication, caregiver mastery and resilience.

Conclusions

For a more comprehensive understanding of patient–caregiver interactions, we recommend using a combination of standardized psychometric tests and a semi-structured interview. The high percentage of emotional strain and depression found in patients and their caregivers facing HGG highlights the necessity of methodical screening for warning signs and consequent initiation of psycho-oncological interventions.

Keywords

Cancer caregiver High-grade glioma Quality of life Oncology Patient–caregiver relationship Semi-structured interview 

Abbreviations

CESDS

Center for Epidemiology Studies Depression Scale

F

Female

GP

General population

HGG

High grade glioma

MDMQ

Multidimensional Mood State Questionnaire

GS

Good mood–bad mood

WM

Attentiveness–tiredness

RU

Calmness–restlessness

SS

Sum Score

M

Male

MMSE

Mini Mental Status Examination

n.s.

Not significant

KPS

Karnofsky Performance Scale

SD

Standard deviation

SF-12

Short Form Medical Outcome Questionnaire

PCS

Physical component summary

MCS

Mental component summary

QoL

Quality of life

WHO

World Health Organization

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed involving human participants were in accordance with the ethical standards of the institutional research committee (approval number 387-11-12122011) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurosurgeryUniversity Hospital of LeipzigLeipzigGermany

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