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Journal of Neuro-Oncology

, Volume 140, Issue 2, pp 359–366 | Cite as

Prediction value of unmeasurable MR enhancement at early stage after gross-total resection on the survival state of patients with high-grade glioma

  • Guanmin Quan
  • Yongli Zheng
  • Jun Chen
  • Bei Hua
  • Xiaoli Ji
  • Kexin Zhang
  • Duo Gao
  • Jianming Lei
  • Tao Yuan
Clinical Study

Abstract

Propose

To explore the value of unmeasurable enhancement pattern of residual cavity in predicting survival at early stage after gross-total resection in high-grade glioma (HGG) patients.

Methods

This retrospective study enrolled consecutive 51 HGG patients with unmeasurable enhancement who underwent gross-total resection followed by concurrent chemoradiotherapy and adjuvant chemotherapy. We evaluated the enhancement patterns of residual cavity on contrast-T1WI made within 1 month after tumor resection (20 ± 3 days). The survival state of different enhancement was compared.

Results

Thin-linear, thick-linear and nodular enhancement were observed in 22 patients (43%), 10 patients (20%), and 19 patients (37%), respectively. The progression-free survival of patients with thin-linear (487, 151–887 days) was longer than those patients with thick-linear (277, 133–573 days), and nodular enhancement (210, 120–765 days) (P = 0.002). The overall survival of patients with thin-linear (774, 457–1343 days) was longer than those with thick-linear (462, 320–678 days), and nodular enhancement (326, 234–1393 days) (P = 0.002). There was no significant difference of orthogonal value between thick-linear and nodular enhancement (0.854), neither between grade III and IV with same enhancement patterns (P = 0.540, P = 0.720).

Conclusions

The unmeasurable enhancement patterns in HGG patients within 1 month after gross-total resection, which might be better than the grade of tumor, holds a potential marker in survival state.

Keywords

Glioma Chemoradiotherapy Outcome Magnetic resonance imaging Enhancement 

Notes

Compliance with ethical standards

Conflict of interest

The authors report no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.The Second Hospital of Hebei Medical UniversityShijiazhuangChina

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