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Journal of Neuro-Oncology

, Volume 140, Issue 1, pp 63–73 | Cite as

Pineal region glioblastomas display features of diffuse midline and non-midline gliomas

  • Randy S. D’Amico
  • George Zanazzi
  • Peter Wu
  • Peter Canoll
  • Jeffrey N. Bruce
Clinical Study

Abstract

Introduction

Pineal region glioblastomas (GBM) are very rare, with approximately 46 cases described in the literature. The epidemiology, pathogenesis, and treatment of these lesions are poorly characterized.

Methods

We identified all cases of pineal region GBM treated surgically at our institution between 1990 and 2017. Demographic and clinical follow-up data were extracted from the medical records for all cases. Pathology was reviewed and classified according to 2016 World Health Organization (WHO) criteria. Specific attention was given to the frequency of histone H3 K27M mutations in these midline gliomas.

Results

Eight patients (seven men, one woman) with pineal region GBM, WHO grade IV, were identified. The most common presenting symptoms were headache (75%), vision changes (75%), and gait imbalance/ataxia (50%). Median age at diagnosis was 48.5 years (range 36–74 years). Radical subtotal resection, via a supracerebellar infratentorial approach, was achieved in 75% of patients. Review of the surgical pathology revealed seven primary GBMs (including one giant cell GBM) and one pineal region GBM that developed three years after resection of a pineal parenchymal tumor of intermediate differentiation. No cases demonstrated evidence of IDH-1 R132H mutation (N = 6) or 1p/19q co-deletion (N = 3). One case tested positive for the histone H3 K27M-mutation. Targeted exome sequencing of 467 cancer-related genes revealed nonsense mutations in ATRX and NF1. Adjuvant radiation and chemotherapy was employed in 87.5% and 75.0% of patients, respectively. Median overall survival (OS) was 15 months (range 2–24 months) from GBM diagnosis.

Conclusions

This study expands the clinical and pathologic spectrum of pineal region GBM, and provides the first report of the genetic landscape of these tumors.

Keywords

Pineal tumor Pineal gland Pineal glioma Glioblastoma Brain tumor Histone H3 K27M 

Abbreviations

GBM

Glioblastoma

WHO

World Health Organization

CNS

Central nervous system

PPTID

Pineal parenchymal tumor of intermediate differentiation

CUMC

Columbia University Medical Center

IRB

Institutional Review Board

MRI

Magnetic resonance imaging

r-STR

Radical subtotal resection

STR

Subtotal resection

OS

Overall survival

EBRT

External beam radiotherapy

SCIT

Supracerebellar infratentorial

IHTC

Interhemispheric transcallosal

COSMIC

Catalogue of somatic mutations in cancer

OMIM

Online mendelian inheritance in man

dbSNP

Single nucleotide polymorphism database

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Randy S. D’Amico
    • 1
  • George Zanazzi
    • 2
  • Peter Wu
    • 1
  • Peter Canoll
    • 2
  • Jeffrey N. Bruce
    • 1
  1. 1.Department of Neurological SurgeryColumbia University Medical CenterNew YorkUSA
  2. 2.Department of Pathology and Cell BiologyColumbia University Medical CenterNew YorkUSA

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