Journal of Neuro-Oncology

, Volume 138, Issue 2, pp 417–424 | Cite as

Surgical treatment of large vestibular schwannomas in patients with neurofibromatosis type 2: outcomes on facial nerve function and hearing preservation

  • Fu ZhaoEmail author
  • Bo Wang
  • Zhijun Yang
  • Qiangyi Zhou
  • Peng Li
  • Xingchao Wang
  • Jing Zhang
  • Junting Zhang
  • Pinan LiuEmail author
Clinical Study


Surgical treatment of vestibular schwannoma (VS) in patients with neurofibromatosis type 2 (NF2) along with functional preservation of cranial nerves is challenging. The aim of this study was to analyze the outcomes of hearing and facial nerve function in patients with NF2 who underwent large-size VS (> 2 cm) surgery. From 2006 to 2016, one hundred and forty NF2 patients were included with 149 large-size VS resections using retrosigmoid approach. Hearing function was classified according to the American Academy of Otolaryngology–Head and Neck Surgery (AAO–HNS) criteria. Preoperative and one-year postoperative facial nerve function were both assessed using the House–Brackmann (H–B) grading scale. A multivariate logistic regression was performed to identify preoperative predictors for facial function outcomes. No operative death we noted. Total tumor removal was achieved in 82.6% of the operated VSs. The anatomical integrity of the facial nerve was preserved in 67.8% of surgeries. Good facial nerve function (H–B Grades I–III) was maintained in 49.6% of patients at 12 months after surgery. Tumor size larger than 3 cm and preoperative facial weakness related with worse outcome of facial nerve function (P < 0.001; for both). Hearing preservation surgeries were attempted in 31 ears. Class B or C hearing according to the AAO–HNS criteria was maintained in 7 ears (22.5%), and measurable hearing was maintained 11 ears (35.5%). It is challenging to maintain hearing and facial nerve function in NF2 patients with large VSs. Early surgical intervention is an appropriate choice to decrease the risk of neurological functions deficit.


Neurofibromatosis type 2 Vestibular schwannoma Hearing preservation Facial nerve Microsurgery 


Author contributions

Conception and design—FZ, PL, JZ; Provision of study materials and/or patients—BW, ZY; Collection and assembly of data—QZ, PL; Data analysis and interpretation—ZF, XW, JZ; Manuscript writing—All authors; Final approval of manuscript—All authors.


This work was supported by the National Natural Science Foundation of China (Grant Numbers: 81372715, 8150110473, 61671187), Beijing Natural Science Foundation of China (Grant Number: 7162057).

Compliance with ethical standards

Conflict of interest

The authors indicated no potential conflicts of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Neural Reconstruction Department, Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina
  2. 2.Department of Neurosurgery, Beijing Tian Tan HospitalCapital Medical UniversityBeijingChina
  3. 3.Beijing Neurosurgical Institute, Beijing Tian Tan HospitalCapital Medical UniversityBeijingChina

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