Journal of Neuro-Oncology

, Volume 137, Issue 3, pp 639–644 | Cite as

Handedness and the risk of glioma

  • Briana Miller
  • Noah C. Peeri
  • Louis Burt Nabors
  • Jordan H. Creed
  • Zachary J. Thompson
  • Carrie M. Rozmeski
  • Renato V. LaRocca
  • Sajeel Chowdhary
  • Jeffrey J. Olson
  • Reid C. Thompson
  • Kathleen M. Egan
Clinical Study

Abstract

Gliomas are the most common type of malignant primary brain tumor and few risk factors have been linked to their development. Handedness has been associated with several pathologic neurological conditions such as schizophrenia, autism, and epilepsy, but few studies have evaluated a connection between handedness and risk of glioma. In this study, we examined the relationship between handedness and glioma risk in a large case–control study (1849 glioma cases and 1354 healthy controls) and a prospective cohort study (326,475 subjects with 375 incident gliomas). In the case–control study, we found a significant inverse association between left handedness and glioma risk, with left-handed persons exhibiting a 35% reduction in the risk of developing glioma [odds ratio (OR) = 0.65, 95% confidence interval (CI) 0.51–0.83] after adjustment for age, gender, race, education, and state of residence; similar inverse associations were observed for GBM (OR = 0.69, 95% CI 0.52–0.91), and non-GBM (OR = 0.59, 95% CI 0.42–0.82) subgroups. The association was consistent in both males and females, and across age strata, and was observed in both glioblastoma and in lower grade tumors. In the prospective cohort study, we found no association between handedness and glioma risk (hazards ratio = 0.92, 95% CI 0.67–1.28) adjusting for age, gender, and race. Further studies on this association may help to elucidate mechanisms of pathogenesis in glioma.

Keywords

Case–control study Cohort study Glioma Glioblastoma Handedness UKBiobank 

Notes

Funding

The research is based in part on the UK Biobank Resource under application number 16944. The work was supported by the National Institutes of Health [Grant Number R01 CA116174]. This research was also funded in part by the National Cancer Institute through the University of Alabama at Birmingham’s Cancer Research Experiences for Students [Grant Number R25Ca076023-17].

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

11060_2018_2759_MOESM1_ESM.pdf (34 kb)
Supplementary material 1 (PDF 34 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Briana Miller
    • 1
  • Noah C. Peeri
    • 2
  • Louis Burt Nabors
    • 1
  • Jordan H. Creed
    • 2
  • Zachary J. Thompson
    • 3
  • Carrie M. Rozmeski
    • 2
  • Renato V. LaRocca
    • 4
  • Sajeel Chowdhary
    • 5
  • Jeffrey J. Olson
    • 6
  • Reid C. Thompson
    • 7
  • Kathleen M. Egan
    • 2
  1. 1.Neuro-Oncology ProgramUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Department of Cancer EpidemiologyH. Lee Moffitt Cancer Center & Research InstituteTampaUSA
  3. 3.Department of Biostatistics and BioinformaticsH. Lee Moffitt Cancer Center & Research InstituteTampaUSA
  4. 4.Norton Cancer InstituteLouisvilleUSA
  5. 5.Neuro-Oncology Program, Lynn Cancer InstituteBoca RatonUSA
  6. 6.Department of NeurosurgeryEmory University School of MedicineAtlantaUSA
  7. 7.Department of Neurological SurgeryVanderbilt University Medical CenterNashvilleUSA

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