Journal of Neuro-Oncology

, Volume 141, Issue 1, pp 13–18 | Cite as

Fluorescence-guided surgery with aminolevulinic acid for low-grade gliomas

  • Benjamin K. Hendricks
  • Nader Sanai
  • Walter StummerEmail author
Topic Review



Fluorescence guided surgery has developed over the last 2 decades as a formidable augmentation strategy to promote maximal safe resection and diagnostic accuracy within gliomas. The majority of the literature evidence supporting this modality utilizes 5-aminolevulinic acid in the setting of high-grade gliomas. The role for fluorescence guided surgery in low-grade gliomas is less well defined.


This review describes the existing literature discussing the utilization of 5-aminolevulinic acid for fluorescence guided surgery in low-grade gliomas, including its pertinence in identification of anaplastic foci and potential role in guiding resection following combination with augmentation strategies for detection.


The advance in operative technology and growth of research analyzing 5-aminolevulinic acid will continue to enhance the role of fluorescence guided surgery within the standard of surgical management for low-grade gliomas.


Microsurgery Fluorophore Anaplastic foci Microscopy Protoporphyrin 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Barrow Neurological InstitutePhoenixUSA
  2. 2.Department of NeurosurgeryUniversity of MünsterMünsterGermany

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