Journal of Neuro-Oncology

, Volume 141, Issue 1, pp 151–158 | Cite as

Use of hyperbaric oxygen therapy in pediatric neuro-oncology: a single institutional experience

  • Yasmin Aghajan
  • Ian Grover
  • Hamza Gorsi
  • Mark Tumblin
  • John Ross CrawfordEmail author
Clinical Study



Hyperbaric oxygen therapy (HBOT) has been utilized as adjunctive treatment of CNS tumors and for radiation necrosis (RN) with reported success. The safety and efficacy in pediatric patients is less understood.


Seven patients (ages 10–23 years, six females) were treated with HBOT (3–60 sessions) for either RN (n = 5) or tumor-associated edema (n = 2). Tumor diagnosis included low-grade glioma (n = 4, two with neurofibromatosis type 1), meningioma (n = 1), medulloblastoma (n = 1) and secondary high grade glioma (n = 1). Prior therapies included: surgery (n = 4), chemotherapy (n = 4) and radiation (N = 5: four focal, one craniospinal). Three underwent biopsy: one confirming RN, one high-grade glioma, and one low-grade glioma. Patients were assessed for clinical and radiographic changes post HBOT.


Median time to clinical and radiographic presentation was 8.5 months (range 6 months–11 years) in those who had prior radiation. Clinical improvement after HBOT (median: 40 sessions) was observed in four of seven patients. Symptoms were stable in two and worsened in one patient. Radiographic improvement was seen in four patients; three had radiographic disease progression. In the subgroup treated for presumed and biopsy-confirmed RN (n = 5), four of five (80%) had clinical and radiographic improvement. There were no long-term adverse events due to HBOT.


HBOT is safe and well-tolerated in pediatric and young adult patients with CNS tumors. Clinical and radiographic improvements were observed in over half of patients. Clinical trials are needed to establish safety and efficacy of HBOT as adjunct therapy in pediatric CNS tumors.


Hyperbaric oxygen Pediatric brain tumors Cerebral radiation necrosis Effects of radiation 


Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Yasmin Aghajan
    • 1
  • Ian Grover
    • 2
  • Hamza Gorsi
    • 3
    • 4
  • Mark Tumblin
    • 4
    • 5
  • John Ross Crawford
    • 3
    • 4
    • 5
    Email author
  1. 1.University of California San Diego School of MedicineLa JollaUSA
  2. 2.Division of Hyperbaric Medicine and Wound Care, Department of Emergency MedicineUniversity of California San Diego Medical SystemSan DiegoUSA
  3. 3.Department of NeurosciencesUniversity of California San DiegoLa JollaUSA
  4. 4.Rady Children’s HospitalSan DiegoUSA
  5. 5.Division of Hematology-Oncology, Department of PediatricsUniversity of California San DiegoLa JollaUSA

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