Journal of Neuro-Oncology

, Volume 137, Issue 2, pp 387–394 | Cite as

Treatment and outcomes of 28 patients with spinal metastasis from gynecological cancer

  • Xin GaoEmail author
  • Chenglong Zhao
  • Shaohui He
  • Tianqi Fan
  • Wei Xu
  • Cheng Yang
  • Tielong LiuEmail author
  • Jianru XiaoEmail author
Clinical Study


The aim of this study was to provide some useful information concerning clinical characteristics, surgical treatment, potential contributing factor and prognostic factors for patients with gynecological cancer (GC) spinal metastasis. We reviewed 28 patients with GC spinal metastasis in our spine tumor center between July 2008 and July 2015. Surgeries were performed on 22 of them. Univariate and multivariate analyses were conducted to identify potential prognostic factors affecting spinal metastasis-free survival (SMFS) and overall survival. The operative patients responded favorably according to decrease of VAS score and increase of Frankel grade after surgery. The 1- and 2-year survival rates in all patients were 60.7 and 41.0%, respectively. Univariate analysis suggested that age at diagnosis with GC was the potential contributing factor for spinal metastasis, while Frankel grade, ECOG-PS, visceral metastasis and chemotherapy were the potential prognostic factors affecting survival. Multivariate analysis indicated that the independent prognostic factors came from visceral metastasis and chemotherapy. Surgery played an important role in improving patients’ quality of life. Patients over 50 years old had a shorter SMFS after diagnosed with GC. Visceral metastasis was an adverse prognostic factor for patients with GC spinal metastasis, while chemotherapy was a favorable one.


Gynecological cancer Spinal metastasis Surgery Spinal metastasis-free survival (SMFS) Overall survival (OS) Prognostic factors 


Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Orthopaedic Oncology Center, Department of Orthopaedics,Changzheng HospitalSecond Military Medical UniversityShanghaiChina

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