Journal of Neuro-Oncology

, Volume 137, Issue 2, pp 357–365 | Cite as

Update on the effect of exogenous hormone use on glioma risk in women: a meta-analysis of case-control and cohort studies

  • Yu-Long Lan
  • Xun Wang
  • Jia-Cheng Lou
  • Bin-Bin Ma
  • Jin-Shan Xing
  • Shuang Zou
  • Bo ZhangEmail author
Clinical Study


Various studies have confirmed the important roles of endogenous hormones in the development of gliomas, while the roles of exogenous hormones remain controversial. Based on case-control studies and cohort studies, a meta-analysis was exerted to explore the effect of two exogenous hormones use (HRT: hormone replacement therapy; OC: oral contraceptives) on glioma risk. 16 eligible studies, including 11 case-control studies and 5 cohort studies, containing 8055027 women, were included in our study. All included studies have reported the relative risks (RRs) or odds ratios (ORs), and 95% confidence intervals (CIs). We use the fixed-effects model to calculate the estimated overall risk. In case-control studies, the risk of glioma was lower in women who had ever been treated with an exogenous hormone than in the control group (HRT: OR 0.91, 95% CI 0.84–0.99; OC: OR 0.99, 95% CI 0.91–1.07). In research of cohort studies, similar results have been obtained (HRT: RR 0.95, 95% CI 0.83–1.08; OC: RR 0.75, 95% CI 0.66–0.84). Our study further confirmed that the use of exogenous hormones has an important impact on the risk of glioma in women. However, more prospective studies are needed to further confirm this conclusion.


Estrogen Glioma Risk assessment Meta-analysis 



This work is supported by grants from National Natural Science Foundation of China (Nos. 81372714, 81672480), Liaoning Provincial Natural Science Foundation of China (No. 201602244), Distinguished Professor Project of Liaoning Province, Special Grant for Translational Medicine, Dalian Medical University (No. 2015002).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

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Supplementary material 1 (DOCX 162 KB)
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Supplementary material 2 (DOC 55 KB)
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Supplementary material 3 (DOC 35 KB)
11060_2017_2725_MOESM4_ESM.doc (56 kb)
Supplementary material 4 (DOC 56 KB)


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© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of NeurosurgeryThe Second Affiliated Hospital of Dalian Medical UniversityDalianPeople’s Republic of China
  2. 2.Department of PharmacyDalian Medical UniversityDalianPeople’s Republic of China
  3. 3.Department of PhysiologyDalian Medical UniversityDalianPeople’s Republic of China

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