Journal of Neuro-Oncology

, Volume 137, Issue 1, pp 57–65 | Cite as

Volumetric response of progressing post-SRS lesions treated with laser interstitial thermal therapy

  • Vivek B. Beechar
  • Sujit S. Prabhu
  • Dhiego Bastos
  • Jeffrey S. Weinberg
  • R. Jason Stafford
  • David Fuentes
  • Kenneth R. Hess
  • Ganesh RaoEmail author
Clinical Study


We analyzed volumetric response of metastatic brain tumors that progressed despite treatment with stereotactic radiosurgery (SRS) after treatment with laser interstitial thermal therapy (LITT). We retrospectively reviewed consecutive patients treated from 1/2012 to 10/2015 with LITT for metastatic brain tumors demonstrating progression after SRS. Volumes were quantified using MRI with contrast-enhanced T1-weighted (T1W) and fluid-attenuated inversion recovery (FLAIR). Fifty lesions from 36 patients were studied. Lesions were assessed prior to LITT, immediately after LITT, 0–90 days after LITT, 90–180 days after LITT, 180–270 days after LITT, and 270–360 days after LITT. The median T1W volume was 5.05 cc (range 0.54–23.31 cc) before LITT treatment (n = 50), 7.70 cc (range 1.72–38.76 cc) 0–90 days after LITT (n = 47), and 3.68 cc (range 1.282–48.31 cc) 180–270 days after LITT (n = 21). The median FLAIR volume was 43.36 cc (range 3.09–233.01 cc) before LITT treatment (n = 50), 37.13 cc (range 3.48–244.23 cc) 0–90 days after LITT (n = 43), 31.68 cc (range 1.6–248.75 cc) 180–270 days after LITT (n = 18). The 6-month FLAIR volume showed a statistically significant reduction compared to pretreatment (p = 0.04). After selecting for cases where patients had two or more post-operative MRIs, we found that 24 lesions (63%) demonstrated an overall downward trend and 14 lesions (37%) demonstrated an upward trend. The median pre-treatment T1W volume for the patients whose lesions demonstrated volumetric reduction after LITT was 3.54 cc (range 0.539–10.06 cc) and for those who did not demonstrate volumetric reduction after LITT it was 8.81 cc (range 0.926–23.313 cc). The pre-treatment tumor volume plays a significant role in determining response to LITT with smaller tumor volumes responding better to LITT than tumors with larger volumes.


Laser interstitial thermal therapy Stereotactic radiosurgery Brain metastasis Metastatic Post-SRS 



This work was supported by the Cancer Center Support Grant from the National Institutes of Health (P30 CA016672).

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Institutional Review Board (Protocol PA17-0169) which grants a waiver of consent for this retrospective study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Vivek B. Beechar
    • 1
  • Sujit S. Prabhu
    • 2
  • Dhiego Bastos
    • 2
  • Jeffrey S. Weinberg
    • 2
  • R. Jason Stafford
    • 3
  • David Fuentes
    • 3
  • Kenneth R. Hess
    • 4
  • Ganesh Rao
    • 2
    • 5
    Email author return OK on get
  1. 1.Department of NeurosurgeryBaylor College of MedicineHoustonUSA
  2. 2.Department of NeurosurgeryMD Anderson Cancer CenterHoustonUSA
  3. 3.Department of Imaging PhysicsMD Anderson Cancer CenterHoustonUSA
  4. 4.Department of BiostatisticsMD Anderson Cancer CenterHoustonUSA
  5. 5.Department of NeurosurgeryMD Anderson Cancer CenterHoustonUSA

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