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Journal of Neuro-Oncology

, Volume 125, Issue 2, pp 317–324 | Cite as

Post-radiosurgical edema associated with parasagittal and parafalcine meningiomas: a multicenter study

  • Jason P. Sheehan
  • Or Cohen-Inbar
  • Rawee Ruangkanchanasetr
  • S. Bulent Omay
  • Judith Hess
  • Veronica Chiang
  • Christian Iorio-Morin
  • Michelle Alonso-Basanta
  • David Mathieu
  • Inga S. Grills
  • John Y. K. Lee
  • Cheng-Chia Lee
  • L. Dade Lunsford
Clinical Study

Abstract

Stereotactic radiosurgery (SRS) offers a high degree of tumor control for benign meningiomas. However, radiosurgery can occasionally incite edema or exacerbate pre-existing peri-tumoral edema. The current study investigates the incidence, timing, and extent of edema around parasagittal or parafalcine meningiomas following SRS. A retrospective multicenter review was undertaken through participating centers in the International Gamma Knife Research Foundation (previously the North American Gamma Knife Consortium or NAGKC). All included patients had a parafalcine or parasagittal meningioma and a minimum of 6 months follow up. The median follow up was 19.6 months (6–158 months). Extent of new or worsening edema was quantitatively analyzed using volumetric analysis; edema indices were longitudinally computed following radiosurgery. Analysis was performed to identify prognostic factors for new or worsening edema. A cohort of 212 patients comprised of 51.9 % (n = 110) females, 40.1 % upfront SRS and 59.9 % underwent adjuvant SRS for post-surgical residual tumor. The median tumor volume at SRS was 5.2 ml. Venous sinus compression or invasion was demonstrated in 25 % (n = 53). The median marginal dose was 14 Gy (8–20 Gy). Tumor volume control was determined in 77.4 % (n = 164 out of 212 patients). Tumor edema progressed and then regressed in 33 % (n = 70), was stable or regressed in 52.8 % (n = 112), and progressively worsened in 5.2 % (n = 11). Tumor location, tumor volume, venous sinus invasion, margin, and maximal dose were found to be significantly related to post-SRS edema in multivariate analysis. SRS affords a high degree of tumor control for patients with parasagittal or parafalcine meningiomas. Nevertheless, SRS can lead to worsening peritumoral edema in a subset of patients such as those with larger tumors (>10 cc) and venous sinus invasion/compression. Long-term follow up is required to detect and appropriately manage post-SRS edema.

Keywords

Radiosurgery Gamma Knife Meningioma Edema 

Notes

Compliance with ethical standards

Disclosure

Dr. Grills have stock ownership and serve on the Board of Directors in a company called Greater Michigan Gamma Knife. Dr. Lunsford is a consultant and has stock in Elekta AB. Dr. Daniel Pieper helped with this work but passed away during the research process.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Jason P. Sheehan
    • 1
  • Or Cohen-Inbar
    • 1
  • Rawee Ruangkanchanasetr
    • 5
  • S. Bulent Omay
    • 2
  • Judith Hess
    • 2
  • Veronica Chiang
    • 2
  • Christian Iorio-Morin
    • 3
  • Michelle Alonso-Basanta
    • 5
  • David Mathieu
    • 3
  • Inga S. Grills
    • 4
  • John Y. K. Lee
    • 5
  • Cheng-Chia Lee
    • 1
  • L. Dade Lunsford
    • 6
  1. 1.Department of Neurological SurgeryUniversity of VirginiaCharlottesvilleUSA
  2. 2.Yale UniversityNew HavenUSA
  3. 3.Université de Sherbrooke and Centre de recherche du CHUSSherbrookeCanada
  4. 4.Beaumont Health SystemRoyal OakUSA
  5. 5.University of PennsylvaniaPhiladelphiaUSA
  6. 6.University of PittsburghPittsburghUSA

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