Journal of Neuro-Oncology

, Volume 119, Issue 1, pp 217–220 | Cite as

The successful treatment of a recurrent intracranial, dural-based plasmacytoma with lenalidomide

  • Craig E. Devoe
  • Jian Yi Li
  • Alexis M. Demopoulos
Letter to the Editor

To the Editor,

A 75 year old woman presented in October of 2008 with new onset symptoms of headaches, difficulty with penmanship, forgetfulness and vertigo. Her past medical history includes sarcoidosis and osteoporosis. As a result of the sarcoidosis, she has chronic interstitial pulmonary fibrosis but refused treatment with chronic steroids. The physical exam was unremarkable and her Karnofsky performance status was 80. She was evaluated for vestibular abnormalities and a magnetic resonance imaging (MRI) with and without gadolinium was obtained. This demonstrated an enhancing extra-axial, dural-based mass in the high biparietal region, measuring 3.0 cm × 6.6 cm in the axial plane and encasing the superior sagittal sinus. This was initially thought to represent a meningioma.

She underwent a stereotactic biopsy of the mass. The Haematoxylin & Eosin (H&E) stained slides showed a hypercellular neoplasm composed of sheets of plasma cells (Fig.  1a). Scattered plasmacytoma cells were...


Multiple Myeloma Meningioma Sarcoidosis Lenalidomide Plasmacytoma 
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Conflict of interest

The authors declare no conflicts of interest.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Craig E. Devoe
    • 1
  • Jian Yi Li
    • 2
  • Alexis M. Demopoulos
    • 3
  1. 1.Monter Cancer Center, Hofstra North Shore-LIJ School of MedicineNorth Shore-Long Island Jewish Health SystemLake SuccessUSA
  2. 2.Hofstra North Shore-LIJ School of MedicineNorth Shore-Long Island Jewish Health SystemLake SuccessUSA
  3. 3.Hofstra North Shore-LIJ School of MedicineNorth Shore-Long Island Jewish Health SystemManhassetUSA

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