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Journal of Neuro-Oncology

, Volume 117, Issue 2, pp 205–215 | Cite as

Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness

  • Emmanuel ChautardEmail author
  • Zangbéwendé Guy Ouédraogo
  • Julian Biau
  • Pierre Verrelle
Topic Review

Abstract

Gathering evidence has revealed that Akt signaling pathway plays an important role in glioma progression and aggressiveness. Among Akt kinases the most studied, Akt1, has been involved in many cellular processes that are in favor of cell malignancy. More recently, the actions of the two other isoforms, Akt2 and Akt3 have emerged in glioma. After a description of Akt pathway activation, we will explore the role of each isoform in malignant glioma that strengthens the current preclinical and clinical studies evaluating the impact of Akt pathway targeting in glioblastomas.

Keywords

Akt Human malignant glioma Resistance to treatment 

Notes

Acknowledgments

The authors would like to sincerely thank Pr. Laurent Morel and Dr Cyrille Saintenac for their critical reading of this manuscript. CREaT (Cancer Resistance Exploring and Targeting) lab is supported by the Ligue Nationale Contre le Cancer (Comité du Puy De Dôme), by the Institut National du Cancer and by the Region Auvergne. Z. G. O. was the recipient of a fellowship from the Ministère des Enseignements Secondaire et Supérieur, Burkina Faso.

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Emmanuel Chautard
    • 1
    • 2
    Email author
  • Zangbéwendé Guy Ouédraogo
    • 1
    • 2
    • 3
  • Julian Biau
    • 1
    • 2
    • 4
  • Pierre Verrelle
    • 1
    • 2
  1. 1.Clermont Université, Université d’AuvergneClermont-FerrandFrance
  2. 2.Centre Jean Perrin, Laboratoire de Radio-Oncologie ExpérimentaleClermont-FerrandFrance
  3. 3.Laboratoire de Pharmacologie, de Toxicologie et de Chimie ThérapeutiqueUniversité de OuagadougouOuagadougouBurkina Faso
  4. 4.Institut CurieCNRS UMR3347, INSERM U2021OrsayFrance

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