Journal of Neuro-Oncology

, Volume 117, Issue 2, pp 205–215

Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness

  • Emmanuel Chautard
  • Zangbéwendé Guy Ouédraogo
  • Julian Biau
  • Pierre Verrelle
Topic Review

DOI: 10.1007/s11060-014-1382-9

Cite this article as:
Chautard, E., Ouédraogo, Z.G., Biau, J. et al. J Neurooncol (2014) 117: 205. doi:10.1007/s11060-014-1382-9

Abstract

Gathering evidence has revealed that Akt signaling pathway plays an important role in glioma progression and aggressiveness. Among Akt kinases the most studied, Akt1, has been involved in many cellular processes that are in favor of cell malignancy. More recently, the actions of the two other isoforms, Akt2 and Akt3 have emerged in glioma. After a description of Akt pathway activation, we will explore the role of each isoform in malignant glioma that strengthens the current preclinical and clinical studies evaluating the impact of Akt pathway targeting in glioblastomas.

Keywords

Akt Human malignant glioma Resistance to treatment 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Emmanuel Chautard
    • 1
    • 2
  • Zangbéwendé Guy Ouédraogo
    • 1
    • 2
    • 3
  • Julian Biau
    • 1
    • 2
    • 4
  • Pierre Verrelle
    • 1
    • 2
  1. 1.Clermont Université, Université d’AuvergneClermont-FerrandFrance
  2. 2.Centre Jean Perrin, Laboratoire de Radio-Oncologie ExpérimentaleClermont-FerrandFrance
  3. 3.Laboratoire de Pharmacologie, de Toxicologie et de Chimie ThérapeutiqueUniversité de OuagadougouOuagadougouBurkina Faso
  4. 4.Institut CurieCNRS UMR3347, INSERM U2021OrsayFrance

Personalised recommendations