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Journal of Neuro-Oncology

, Volume 115, Issue 3, pp 505–511 | Cite as

Radiosurgery for central neurocytoma: long-term outcome and failure pattern

  • Jin Wook Kim
  • Dong Gyu Kim
  • Hyun-Tai Chung
  • Seung Hong Choi
  • Jung Ho Han
  • Chul-Kee Park
  • Chae-Yong Kim
  • Sun Ha Paek
  • Hee-Won Jung
Clinical Study

Abstract

Despite the favorable outcomes of radiosurgery for central neurocytoma (CN), these results are based on case series that included a limited number of patients and short follow-up periods because of the scarcity of CN. Because CN is a benign tumor with an indolent clinical course, long-term follow-up and analysis of failure pattern are required for the establishment of the role of radiosurgery in the management of CN. Twenty consecutive patients (10 patients who received Gamma Knife radiosurgery (GKRS) as a primary treatment and 10 patients who received GKRS as a secondary treatment) with a radiological follow-up period ≥36 months were included in this study. The mean radiological follow-up duration was 100 months (range 43–149 months). The mean tumor volume was 10.4 cm3 (range 0.4–36.4 cm3) and the mean marginal dose was 15.4 Gy (range 9–20 Gy). Local control failure was found in six patients at the last radiological follow-up. Overall actuarial local control rates were 89.5 % at 5 years and 83.1 % at 10 years. The primary GKRS group included two cases with local failure, with cyst formation or local recurrence. In contrast, in the secondary GKRS group, local control failure was found in four cases (including three cases with an “out-of-field recurrence” pattern) and occurred earlier compared with the primary GKRS group. Our study suggests that GKRS could be a primary or secondary treatment option for CN. However, long-term radiological follow-up is mandatory. In particular, more careful consideration during margin delineation and planning procedure is required in the secondary GKRS group.

Keywords

Central neurocytoma Gamma Knife radiosurgery Long-term outcome Local tumor control 

Abbreviations

CN

Central neurocytoma

RT

Radiation therapy

GKRS

Gamma Knife radiosurgery

LINAC

Linear accelerator

MR

Magnetic resonance

Notes

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jin Wook Kim
    • 1
  • Dong Gyu Kim
    • 1
  • Hyun-Tai Chung
    • 1
  • Seung Hong Choi
    • 2
  • Jung Ho Han
    • 1
  • Chul-Kee Park
    • 1
  • Chae-Yong Kim
    • 1
  • Sun Ha Paek
    • 1
  • Hee-Won Jung
    • 1
  1. 1.Department of NeurosurgerySeoul National University College of MedicineSeoulKorea
  2. 2.Department of RadiologySeoul National University College of MedicineSeoulKorea

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