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Journal of Neuro-Oncology

, Volume 115, Issue 3, pp 401–409 | Cite as

Gliomas of the posterior fossa in adults

  • Ido Strauss
  • Tali Jonas-Kimchi
  • Felix Bokstein
  • Deborah Blumenthal
  • Jonathan Roth
  • Razi Sitt
  • Jefferson Wilson
  • Zvi Ram
Clinical Study

Abstract

Infratentorial gliomas are relatively rare tumors compared to their supratentorial counterparts. As such they have not been extensively characterized as a group and are usually excluded from clinical studies. Using our database we aimed to characterize adult gliomas involving the posterior fossa with respect to their clinical behavior and prognostic factors. We reviewed our neurosurgical and neuro-oncological data bases for adult patients diagnosed with gliomas involving the posterior fossa between 1996 and 2010. Of 1,283 glioma patients, 57 patients with gliomas involving the posterior fossa were identified (4.4 %). Tumors were further classified by location as primary brainstem (n = 21) and primary cerebellar (n = 18) tumors. On univariate analysis survival was correlated to tumor grade and KPS. In addition we have identified a unique group of patients (n = 18) with previously diagnosed supratentorial gliomas who subsequently developed noncontiguous secondary infratentorial extension of their tumors with subsequent rapid clinical deterioration. Gliomas of the posterior fossa comprise a heterogeneous group of tumors. Histological grade of the tumor was found to be the main prognostic factor. Survival of primary cerebellar gliomas is comparable to supra-tentorial gliomas, while brainstem gliomas in adults fare better than in the pediatric population. Secondary extension of supratentorial gliomas to the posterior fossa signifies a grave prognosis.

Keywords

Glioma Posterior fossa Brainstem Cerebellum Secondary extension 

Notes

Conflict of interest

None.

Supplementary material

11060_2013_1231_MOESM1_ESM.doc (38 kb)
Supplementary material 1 (DOC 38 kb)
11060_2013_1231_MOESM2_ESM.doc (41 kb)
Supplementary material 2 (DOC 41 kb)

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Ido Strauss
    • 1
  • Tali Jonas-Kimchi
    • 2
  • Felix Bokstein
    • 3
  • Deborah Blumenthal
    • 3
  • Jonathan Roth
    • 1
  • Razi Sitt
    • 1
  • Jefferson Wilson
    • 4
  • Zvi Ram
    • 1
  1. 1.Department of NeurosurgeryTel Aviv Medical CenterTel AvivIsrael
  2. 2.Neuroradiology UnitTel Aviv Medical CenterTel AvivIsrael
  3. 3.Neuro-Oncology DivisionTel Aviv Medical CenterTel AvivIsrael
  4. 4.Department of NeurosurgeryToronto Western HospitalTorontoCanada

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