Journal of Neuro-Oncology

, Volume 113, Issue 3, pp 479–483 | Cite as

Prognostic role for diffusion-weighted imaging of pediatric optic pathway glioma

  • K. W. Yeom
  • R. M. LoberEmail author
  • J. B. Andre
  • P. G. Fisher
  • P. D. Barnes
  • M. S. B. Edwards
  • S. Partap
Clinical Study


Optic pathway glioma (OPG) has an unpredictable course, with poor correlation between conventional imaging features and tumor progression. We investigated whether diffusion-weighted MRI (DWI) predicts the clinical behavior of these tumors. Twelve children with OPG (median age 2.7 years; range 0.4–6.2 years) were followed for a median 4.4 years with DWI. Progression-free survival (time to requiring therapy) was compared between tumors stratified by apparent diffusion coefficient (ADC) from initial pre-treatment scans. Tumors with baseline ADC greater than 1,400 × 10−6 mm2/s required treatment earlier than those with lower ADC (log-rank p = 0.002). In some cases, ADC increased leading up to treatment, and declined following treatment with surgery, chemotherapy, or radiation. Baseline ADC was higher in tumors that eventually required treatment (1,562 ± 192 × 10−6 mm2/s), compared with those conservatively managed (1,123 ± 114 × 10−6 mm2/s) (Kruskal–Wallis test p = 0.013). Higher ADC predicted earlier tumor progression in this cohort and in some cases declined after therapy. Evaluation of OPG with DWI may therefore be useful for predicting tumor behavior and assessing treatment response.


MRI DWI ADC Optic pathway glioma 


Conflict of interest

This study was performed without grant support or industry sponsorship. There are no financial disclosures or conflicts of interest.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • K. W. Yeom
    • 1
  • R. M. Lober
    • 2
    Email author
  • J. B. Andre
    • 3
  • P. G. Fisher
    • 4
  • P. D. Barnes
    • 1
  • M. S. B. Edwards
    • 2
  • S. Partap
    • 4
  1. 1.Division of Pediatric Radiology, Department of RadiologyStanford University School of MedicineStanfordUSA
  2. 2.Division of Pediatric Neurosurgery, Department of NeurosurgeryStanford University School of MedicineStanfordUSA
  3. 3.Department of RadiologyUniversity of Washington Medical CenterSeattleUSA
  4. 4.Division of Child Neurology, Department of NeurologyStanford University School of MedicineStanfordUSA

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